ArticleIntensive care medicine2006
Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- Association Between IL10 Polymorphisms and the Susceptibility to Sepsis: A Meta-Analysis.Biochemical genetics · 2023Pooled it
- Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.Epidemiology and infection · 2015Pooled it
- Quantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis.Molecular biology reports · 2013Pooled it
- Association of the IL-10 polymorphisms and periodontitis: a meta-analysis.Molecular biology reports · 2012Pooled it
- Influence ofInternational journal of molecular sciences · 2022Article
- Review
- Variation in the Untranslated Genome and Susceptibility to Infections.Frontiers in immunology · 2018Review
- The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2017Review
- Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study.Italian journal of pediatrics · 2017Article
- Medical mycology and fungal immunology: new research perspectives addressing a major world health challenge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis.Immunologic research · 2016Article
- Interleukin-10 -1082 G/A gene polymorphisms in Egyptian children with CAP: A case-control study.Medicine · 2016Article
- [Association of single nucleotide polymorphism in exon of transient receptor potential melastatin 2 gene with sepsis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Observational
- Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.Clinical and experimental immunology · 2015Article
- Significance of -1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Human genetic susceptibility to Candida infections.Medical mycology · 2012Review
- Pro-inflammatory genetic profile and familiarity of acute myocardial infarction.Immunity & ageing : I & A · 2012Article
- Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- The influence of genetic variation on innate immune activation in an environment with high infectious pressure.Genes and immunity · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the -1082 (A/G) polymorphism in the promoter of the IL-10 gene in terms of IL-10 production from stimulated peripheral blood mononuclear cells (PBMC) and to evaluate the relationship of this polymorphism with susceptibility to severe sepsis and the outcome of the disease.
designCase-control study.
settingResearch laboratory of Molecular Biology and Immunology and University Hospital ICU, Faculty of Medicine, Trakia University. PATIENTS: A total of 53 healthy volunteers and 33 patients in ICU meeting the criteria for severe sepsis were included. MEASUREMENTS AND
resultsThe amplification refractory mutation system PCR was used for IL-10-1082 polymorphism detection. Isolated PBMC were stimulated with either C3-binding glycoprotein (C3bgp), lipopolysaccharide (LPS), phytohemagglutinin (PHA),or pokeweed mitogen (PWM). IL-10 production was measured in culture supernatants. The AA genotype was associated with lower IL-10 production in LPS-, PHA- or PWM-stimulated healthy PBMC. Patients with severe sepsis had significant elevation of A allele, compared with healthy controls (74.2% vs 52.8%; p=0.0062). Carriage of at least one copy of IL-10-1082 G allele in sepsis patients and in healthy controls resulted in a statistically significant increase in IL-10 production from stimulated PBMC. Surviving sepsis patients had a significant decrease of IL-10-1082 allele G frequency, compared with controls (17% vs 47.2%; p=0.012). An association between increased IL-10 production and poor outcome from sepsis was observed.
conclusionThe A allele of the -1082 polymorphism in the interleukin-10 gene promoter is associated with sepsis susceptibility, whereas G allele is associated with higher stimulated interleukin-10 production and increased mortality in severe sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.