Evidence map›Paper›PMID 16434737›Full record

Trial reportJournal of dental research2006

Fluoride varnish efficacy in preventing early childhood caries.

J A Weintraub, F Ramos-Gomez, B Jue, S Shain, C I Hoover, J D B Featherstone, S A Gansky

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of dental research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 101 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 4 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00066963 phase3completednot on this map

Comprehensive Oral Health Center for Discovery: New Strategies for Enhancing Tissue Integrity and Repair Early Childhood Caries: Prevention and Treatment Outcomes

TypeinterventionalSponsorUniversity of California, San FranciscoRan2002 to 2006Enrolled376ConditionsDental CariesArmsFluoride Varnish
NCT00497029 nacompletednot on this map

Early Childhood Caries Prevention at a Pediatric Clinic

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2004 to 2006Enrolled219ConditionsDental CariesArmsfluoride varnish, patient education
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 4 syntheses or guidelines pooled it, 329 citations in OpenAlex.

  1. [Meta-analysis of sealants versus fluoride varnishes for the prevention of occlusal surface caries in children's first permanent molars].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Pooled it
  2. Guideline
  3. Fluoride varnishes for preventing dental caries in children and adolescents.The Cochrane database of systematic reviews · 2013
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Review
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J A WeintraubCenter to Address Disparities in Children's Oral Health and Comprehensive Oral Health Research Center of Discovery, University of California, San Francisco School of Dentistry, San Francisco, CA 94143-1361, USA. Jane.Weintraub@ucsf.edu
F Ramos-Gomez
B Jue
S Shain
C I Hoover
J D B Featherstone
S A Gansky
California Health and Human Services Agency · USUniversity of California, San Francisco · US

Funding

Vision Awards for GM Lead Users GroupU54DE014251 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEINTRAUB, JANE A · 2001 to 2007
$10.9M
TRANSGENIC MODELS WITH SKELETAL REPAIR PHENOTYPESP60DE013058 · NIDCR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI DAMSKY, CAROLINE H · 1999 to 2003
$9.1M
NIDCR NIH HHS P60 DE013058NIDCR NIH HHS P60 DE13058NIDCR NIH HHS U54 DE014251NIDCR NIH HHS U54 DE142501
6 · The paper itself

Abstract

To determine the efficacy of fluoride varnish (5% NaF, Duraphat, Colgate) added to caregiver counseling to prevent early childhood caries, we conducted a two-year randomized, dental-examiner-masked clinical trial. Initially, 376 caries-free children, from low-income Chinese or Hispanic San Francisco families, were enrolled (mean age +/- standard deviation, 1.8 +/- 0.6 yrs). All families received counseling, and children were randomized to the following groups: no fluoride varnish, fluoride varnish once/year, or fluoride varnish twice/year. An unexpected protocol deviation resulted in some children receiving less active fluoride varnish than assigned. Intent-to-treat analyses showed a fluoride varnish protective effect in caries incidence, p < 0.01. Analyzing the number of actual, active fluoride varnish applications received resulted in a dose-response effect, p < 0.01. Caries incidence was higher for 'counseling only' vs. 'counseling + fluoride varnish assigned once/year' (OR = 2.20, 95% CI 1.19-4.08) and 'twice/year' (OR = 3.77, 95% CI 1.88-7.58). No related adverse events were reported. Fluoride varnish added to caregiver counseling is efficacious in reducing early childhood caries incidence.

Indexed as

Cariostatic AgentsChild, PreschoolDental CariesDMF IndexDose-Response Relationship, DrugFemaleFluorides, TopicalHealth Education, DentalHumansInfantLinear ModelsMaleSingle-Blind MethodSodium FluorideStatistics, NonparametricCariostatic AgentsFluorides, TopicalSodium Fluoridesodium fluoride topical preparation

Identifiers

PMID16434737
PMCPMC2257982
OpenAlexW2152500341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.