ArticleJournal of dental research2006
Reduced antigenicity of type I collagen and proteoglycans in sclerotic dentin.
Article in Journal of dental research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Phosphoric acid esters cannot replace polyvinylphosphonic acid as phosphoprotein analogs in biomimetic remineralization of resin-bonded dentin.Dental materials : official publication of the Academy of Dental Materials · 2009Trial
- Bond preservation in caries-affected dentin restored with acrylamide-based adhesives.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Hypochlorous acid as a potential cavity conditioner for caries-affected dentin.Scientific reports · 2025Article
- Enhancing caries-affected dentin bonding with a mussel-inspired primer.Frontiers in bioengineering and biotechnology · 2025Article
- Osteoproductivity in Experimentally Induced Cranial Bone Defects in Rabbits.Iranian biomedical journal · 2023Article
- Dentin Degradation: From Tissue Breakdown to Possibilities for Therapeutic Intervention.Current oral health reports · 2023Article
- Dentin on the nanoscale: Hierarchical organization, mechanical behavior and bioinspired engineering.Dental materials : official publication of the Academy of Dental Materials · 2017Review
- Role of dentin MMPs in caries progression and bond stability.Journal of dental research · 2015Review
- Immunocytochemical detection of dentin matrix proteins in primary teeth from patients with dentinogenesis imperfecta associated with osteogenesis imperfecta.European journal of histochemistry : EJH · 2014Article
- Dentin biomodification: strategies, renewable resources and clinical applications.Dental materials : official publication of the Academy of Dental Materials · 2014Review
- Caries arresting effect of silver diamine fluoride on dentine carious lesion with S. mutans and L. acidophilus dual-species cariogenic biofilm.Medicina oral, patologia oral y cirugia bucal · 2013Article
- Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration.Frontiers in physiology · 2013Review
- Site specific properties of carious dentin matrices biomodified with collagen cross-linkers.American journal of dentistry · 2013Article
- Preventing root caries development under oral biofilm challenge in an artificial mouth.Medicina oral, patologia oral y cirugia bucal · 2013Article
- Increased matrix metalloproteinase-2 and bone sialoprotein response to human coronal caries.Caries research · 2011Article
- Immunohistochemical and biochemical assay of versican in human sound predentine/dentine matrix.European journal of histochemistry : EJH · 2009Review
- Biomechanical perspective on the remineralization of dentin.Caries research · 2009Article
- Protein biomarkers of external root resorption: a new protein extraction protocol. Are we going in the right direction?Dental press journal of orthodonticsArticle
- Current considerations concerning endodontically treated teeth: alteration of hard dental tissues and biomechanical properties following endodontic therapy.Journal of medicine and lifeReview
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Antigenic alterations to the dentin organic matrix may be detected by an immunohistochemical approach. We hypothesized that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions. Transverse sections were prepared from carious teeth in the sclerotic zone and normal hard dentin. A double-immunolabeling technique was performed on these sections, with anti-type I collagen and anti-chondroitin 4/6 sulfate monoclonal primary antibodies. We used gold-conjugated secondary antibodies to visualize the distribution of intact collagen fibrils and proteoglycans by high-resolution SEM. For sclerotic dentin, labeling densities were 19.57 +/- 3.01/microm2 for collagen and 9.84 +/- 2.62/microm2 for proteoglycans. For normal hard dentin, values were 35.20 +/- 2.73/microm2 and 17.03 +/- 1.98/microm2, respectively. Distribution of intact collagen fibrils and proteoglycans in sclerotic dentin was significantly lower than in normal hard dentin. Reductions in antigenicity from the organic matrix of sclerotic dentin under caries lesions raise concern about the potential of intrafibrillar remineralization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.