ReviewThe anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology2006
Molecular determinants of the face map development in the trigeminal brainstem.
Review in The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.Human molecular genetics · 2020Article
- Development of tactile sensory circuits in the CNS.Current opinion in neurobiology · 2018Review
- Alignment of EphA4 and ephrin-B2 expression patterns with developing modularity in the lateral cortex of the inferior colliculus.The Journal of comparative neurology · 2018Article
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- Development of regional specificity of spinal and medullary dorsal horn neurons.World journal of biological chemistry · 2016Review
- Neonatal sensory nerve injury-induced synaptic plasticity in the trigeminal principal sensory nucleus.Experimental neurology · 2016Review
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- Null mutations of NT-3 and Bax affect trigeminal ganglion cell number but not brainstem barrelette pattern formation.Somatosensory & motor research · 2013Article
- Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Barrelettes without barrels in the American water shrew.PloS one · 2013Article
- Development and critical period plasticity of the barrel cortex.The European journal of neuroscience · 2012Review
- Thrombospondins as key regulators of synaptogenesis in the central nervous system.Matrix biology : journal of the International Society for Matrix Biology · 2012Review
- Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons.Development (Cambridge, England) · 2012Article
- The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex.Somatosensory & motor research · 2012Article
- How do barrels form in somatosensory cortex?Annals of the New York Academy of Sciences · 2011Review
- N-methyl-D-aspartate receptor subunit composition in the rat trigeminal principal nucleus remains constant during postnatal development and following neonatal denervation.Neuroscience · 2011Article
- The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.Molecular and cellular neurosciences · 2010Article
- Mapping the face in the somatosensory brainstem.Nature reviews. Neuroscience · 2010Review
- The role of astrocyte-secreted matricellular proteins in central nervous system development and function.Journal of cell communication and signaling · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The perception of external sensory information by the brain requires highly ordered synaptic connectivity between peripheral sensory neurons and their targets in the central nervous system. Since the discovery of the whisker-related barrel patterns in the mouse cortex, the trigeminal system has become a favorite model for study of how its connectivity and somatotopic maps are established during development. The trigeminal brainstem nuclei are the first CNS regions where whisker-specific neural patterns are set up by the trigeminal afferents that innervate the whiskers. In particular, barrelette patterns in the principal sensory nucleus of the trigeminal nerve provide the template for similar patterns in the face representation areas of the thalamus and subsequently in the primary somatosensory cortex. Here, we describe and review studies of neurotrophins, multiple axon guidance molecules, transcription factors, and glutamate receptors during early development of trigeminal connections between the whiskers and the brainstem that lead to emergence of patterned face maps. Studies from our laboratories and others' showed that developing trigeminal ganglion cells and their axons depend on a variety of molecular signals that cooperatively direct them to proper peripheral and central targets and sculpt their synaptic terminal fields into patterns that replicate the organization of the whiskers on the muzzle. Similar mechanisms may also be used by trigeminothalamic and thalamocortical projections in establishing patterned neural modules upstream from the trigeminal brainstem.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.