ArticleIntensive care medicine2006
Levels of vancomycin in the cerebral interstitial fluid after severe head injury.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Penetration of Vancomycin into the Cerebrospinal Fluid: A Systematic Review.Clinical pharmacokinetics · 2017Pooled it
- Vancomycin Penetration in Brain Extracellular Fluid of Patients with Post-Surgical Central Nervous System Infections: An Exploratory Study.Medicina (Kaunas, Lithuania) · 2025Article
- An In Vitro Calibration Model for Vancomycin Quantification in Brain Extracellular Fluid: Toward Improved Dosing in Postoperative Infections.Pharmacology research & perspectives · 2025Article
- Therapeutic Drug Distribution across the Mouse Brain Is Heterogeneous as Revealed by In Vivo, Spatially Resolved Aptamer-Based Sensing.ACS pharmacology & translational science · 2025Article
- Early Intraventricular Antibiotic Therapy Improved In-Hospital-Mortality in Neurocritical Patients with Multidrug-Resistant Bacterial Nosocomial Meningitis and Ventriculitis.Neurocritical care · 2024Article
- Concentrations of Cefuroxime in Brain Tissue of Neurointensive Care Patients.Antimicrobial agents and chemotherapy · 2018Article
- [Antibiotic diffusion to central nervous system].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Review
- Intrathecal and intraventricular antibiotics for postoperative Gram-negative meningitis and ventriculitis.Surgical neurology international · 2017Article
- Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury.Antimicrobial agents and chemotherapy · 2013Article
- Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.Journal of pharmacokinetics and pharmacodynamics · 2013Review
- Pharmacokinetics of single-dose daptomycin in patients with suspected or confirmed neurological infections.Antimicrobial agents and chemotherapy · 2011Article
- Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections.Clinical microbiology reviews · 2010Review
- Correlation between brain interstitial and total serum cortisol levels in traumatic brain injury. A preliminary study.Journal of endocrinological investigation · 2010Article
- Pharmacokinetics of antibiotics or antifungal drugs in intensive care units.Current infectious disease reports · 2009Article
- Comment on "Levels of vancomycin in the cerebral interstitial fluid after severe head injury" by Caricato et al.Intensive care medicine · 2006Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the concentrations of vancomycin in the cerebral interstitial fluid after intravenous administration by multiple boli.
designProspective non randomized study
settingUniversity hospital general ICU. PATIENTS: Four patients undergone to craniotomy for evacuation of cerebral posttraumatic hemorrhage, who developed pneumonia 4-7 days from the injury
methodsTwo microdialysis catheters were placed in each patient: one in the edematous brain surrounding the focal lesion and one in the subcutaneous tissue of abdomen. Levels of vancomycin were measured in serum and in the microdialysates samples.
resultsPlasmatic concentration of 10-15 microg/ml in the trough level was obtained after four administrations of vancomycin. Levels of vancomycin in the subcutaneous tissue was above minimum inhibitory concentrations in all patients after the second administration. Mean serum/brain ratio was 8%. Cerebral interstitial concentration of vancomycin was never above minimum inhibitory concentrations; its maximum value was 1.2 microg/ml.
conclusionsIn edematous brain close to a posttraumatic hemorrhage the levels of vancomycin do not differ from that in healthy subjects. At these plasmatic concentrations cerebral interstitial levels of vancomycin were insufficient while subcutaneous interstitial levels were effective for clinical use.
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