ArticleProceedings of the National Academy of Sciences of the United States of America2006
Variable molecular clocks in hominoids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Parting ways: Pan-Homo divergence revisited.Primates; journal of primatology · 2026Review
- Review
- Accelerated cell-type-specific regulatory evolution of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The divergence of mutation rates and spectra across the Tree of Life.EMBO reports · 2023Review
- The impact of genetic modifiers on variation in germline mutation rates within and among human populations.Genetics · 2022Article
- Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution.Frontiers in genetics · 2021Article
- Dynamic evolution of great ape Y chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates.American journal of physical anthropology · 2020Article
- The Estimated Pacemaker for Great Apes Supports the Hominoid Slowdown Hypothesis.Evolutionary bioinformatics online · 2019Article
- High-resolution comparative analysis of great ape genomes.Science (New York, N.Y.) · 2018Article
- Evolution of Brain Active Gene Promoters in Human Lineage Towards the Increased Plasticity of Gene Regulation.Molecular neurobiology · 2018Article
- Phylogeography of the sand dollar genus Encope: implications regarding the Central American Isthmus and rates of molecular evolution.Scientific reports · 2017Article
- Variation in the molecular clock of primates.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Life history effects on the molecular clock of autosomes and sex chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Properties and rates of germline mutations in humans.Trends in genetics : TIG · 2013Review
- First comparative study of primate morphological and molecular evolutionary rates including muscle data: implications for the tempo and mode of primate and human evolution.Journal of anatomy · 2013Article
- Accelerated exon evolution within primate segmental duplications.Genome biology · 2013Article
- Article
- Variation in heterozygosity predicts variation in human substitution rates between populations, individuals and genomic regions.PloS one · 2013Article
- Revising the human mutation rate: implications for understanding human evolution.Nature reviews. Genetics · 2012Review
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4 authors.
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Abstract
Generation time is an important determinant of a neutral molecular clock. There are several human-specific life history traits that led to a substantially longer generation time in humans than in other hominoids. Indeed, a long generation time is considered an important trait that distinguishes humans from their closest relatives. Therefore, humans may exhibit a significantly slower molecular clock as compared to other hominoids. To investigate this hypothesis, we performed a large-scale analysis of lineage-specific rates of single-nucleotide substitutions among hominoids. We found that humans indeed exhibit a significant slowdown of molecular evolution compared to chimpanzees and other hominoids. However, the amount of fixed differences between humans and chimpanzees appears extremely small, suggesting a very recent evolution of human-specific life history traits. Notably, chimpanzees also exhibit a slower rate of molecular evolution compared to gorillas and orangutans in the regions analyzed.
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