ArticleProceedings of the National Academy of Sciences of the United States of America2006
Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Structural causes of pattern formation and loss through model-independent bifurcation analysis.Journal of mathematical biology · 2025Article
- Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018Review
- Enhanced Delta-Notch Lateral Inhibition Model Incorporating Intracellular Notch Heterogeneity and Tension-Dependent Rate of Delta-Notch Binding that Reproduces Sprouting Angiogenesis Patterns.Scientific reports · 2018Article
- Review
- Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression.Nature communications · 2015Article
- A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva.BMC bioinformatics · 2015Article
- Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis.Journal of the Royal Society, Interface · 2014Article
- A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans.Frontiers in genetics · 2013Article
- Mathematical study of the role of Delta/Notch lateral inhibition during primary branching of Drosophila trachea development.Biophysical journal · 2012Article
- Geometry, epistasis, and developmental patterning.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network.Current biology : CB · 2011Article
- Hybrid Modeling of Cell Signaling and Transcriptional Reprogramming and Its Application in C. elegans Development.Frontiers in genetics · 2011Article
- The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination.Tissue engineering. Part B, Reviews · 2009Review
- Predicting phenotypic diversity and the underlying quantitative molecular transitions.PLoS computational biology · 2009Article
- Modeling the dynamics of transcriptional gene regulatory networks for animal development.Developmental biology · 2009Review
- Intraspecific evolution of the intercellular signaling network underlying a robust developmental system.Genes & development · 2008Article
- Negative autoregulation by FAS mediates robust fetal erythropoiesis.PLoS biology · 2007Article
- The zebrafish: scalable in vivo modeling for systems biology.Wiley interdisciplinary reviews. Systems biology and medicineReview
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3 authors.
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Abstract
During vulval development in Caenorhabditis elegans, six precursor cells acquire a spatial pattern of distinct cell fates. This process is guided by a gradient in the soluble factor, LIN-3, and by direct interactions between neighboring cells mediated by the Notch-like receptor, LIN-12. Genetic evidence has revealed that these two extracellular signals are coupled: lateral cell-cell interactions inhibit LIN-3-mediated signaling, whereas LIN-3 regulates the extent of lateral signaling. To elucidate the quantitative implications of this coupled network topology for cell patterning during vulval development, we developed a mathematical model of LIN-3/LIN-12-mediated signaling in the vulval precursor cell array. Our analysis reveals that coupling LIN-3 and LIN-12 amplifies cellular perception of the LIN-3 gradient and polarizes lateral signaling, both of which enhance fate segregation beyond that achievable by an uncoupled system.
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