ArticleProceedings of the National Academy of Sciences of the United States of America2006
An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Sctensor detects many-to-many cell-cell interactions from single cell RNA-sequencing data.BMC bioinformatics · 2023Article
- Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model.Neurobiology of disease · 2023Article
- Article
- Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance.PloS one · 2013Article
- APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.Molecular neurodegeneration · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have earlier proposed that a cell-cell interaction, mediated by the specific binding of molecules of the beta-amyloid precursor protein (beta-APP) on one cell surface with molecules of presenilin (PS) on the other cell surface, is a required initial step in the ultimate production of beta-amyloid (Abeta) from beta-APP. Abeta is widely believed to be the neurotoxic agent in Alzheimer's disease. In this paper, we test this proposal by modifying cells to express surface beta-APP but no PS, and other cells to express surface PS but no beta-APP. Coculturing these two cell populations at appropriate cell densities produces substantial amounts of Abeta that appear both in cell extracts and culture media. Such Abeta production could occur only if the two cell types interacted with one another to provide the beta-APP and the PS required for the generation of Abeta. The addition to the coculture, from the start, of the soluble specific N-terminal domain of the appropriate PS significantly reduces the amount of Abeta produced. These and related experiments, therefore, suggest a very different mechanism for Abeta production than the one that is currently widely accepted.
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Registered trials
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