Evidence map›Paper›PMID 16429398›Full record

ReviewBiopolymers2006

Heat capacity changes associated with nucleic acid folding.

Peter J Mikulecky, Andrew L Feig

Abstract readReview
In one paragraph

Review in Biopolymers, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Thermophysical Properties of a tRNA Isodecoder.The journal of physical chemistry. B · 2026
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  7. Review
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  10. Universal cold RNA phase transitions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter J MikuleckyDepartment of Chemistry, Indiana University, 800 East Kirkwood Avenue Bloomington, IN 47401, USA.
Andrew L Feig

Funding

RNA Cold DenaturationR01GM065430 · NIGMS · WAYNE STATE UNIVERSITY · PI FEIG, ANDREW L · 2003 to 2007
$1.1M
NIGMS NIH HHS R01 GM065430
6 · The paper itself

Abstract

Whereas heat capacity changes (DeltaCPs) associated with folding transitions are commonplace in the literature of protein folding, they have long been considered a minor energetic contributor in nucleic acid folding. Recent advances in the understanding of nucleic acid folding and improved technology for measuring the energetics of folding transitions have allowed a greater experimental window for measuring these effects. We present in this review a survey of current literature that confronts the issue of DeltaCPs associated with nucleic acid folding transitions. This work helps to gather the molecular insights that can be gleaned from analysis of DeltaCPs and points toward the challenges that will need to be overcome if the energetic contribution of DeltaCP terms are to be put to use in improving free energy calculations for nucleic acid structure prediction.

Indexed as

Hot TemperatureNucleic Acid ConformationNucleic Acid DenaturationCalorimetry, Differential ScanningDNAHydrogen BondingModels, ChemicalModels, MolecularRNAThermodynamicsDNARNA

Identifiers

PMID16429398
PMCPMC2465468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.