ArticleExperimental brain research2006
A multiphasic role for Pax7 in tectal development.
Article in Experimental brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts.Biology open · 2018Article
- Conserved localization of Pax6 and Pax7 transcripts in the brain of representatives of sarcopterygian vertebrates during development supports homologous brain regionalization.Frontiers in neuroanatomy · 2014Article
- Regional expression of Pax7 in the brain of Xenopus laevis during embryonic and larval development.Frontiers in neuroanatomy · 2013Article
- Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7.Developmental biology · 2008Article
- Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice.Experimental brain research · 2007Article
- Graded ephrin-A2 expression in the developing hamster superior colliculus.Experimental brain research · 2006Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The optic tectum differentiates from the mesencephalic alar plate and matures into a characteristically laminated structure. Evidence presented here suggests a role for Pax7 in all stages of development of tectal architecture, from regionalisation to specification of neurons and tectal topography. Analysis of Pax7 expression profiles over a range of developmental stages (E2-E12) suggests a biphasic role for Pax7: initially Pax7 expressing cells in the proliferative neuroepithelial layer establish tectal polarity whereas later Pax7 is expressed in neurons of the retino-recipient precursor stratum griseum et fibrosum superficiale (sgfs) laminae where graded levels may establish tectal topography. Furthermore, co-localisation immunofluorescence confirmed that Pax7 is initially expressed in the majority of proliferative neuroepithelial cells and later in a subset of neurons of the sgfs laminae.
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