ArticlePlant molecular biology2006
AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis.
Article in Plant molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 129 citations in OpenAlex.
- CaSAP8-CaDSK2a Negative Feedback Loop Modulates Pepper Thermotolerance by Integrating Transcriptional Repression and Protein Degradation.Plant, cell & environment · 2026Article
- The Arabidopsis ARF3-AIP1/2-SAP18 module specifies the root stem cell niche in response to auxin.The Plant cell · 2026Article
- SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Plant Signaling Hormones and Transcription Factors: Key Regulators of Plant Responses to Growth, Development, and Stress.Plants (Basel, Switzerland) · 2025Review
- Nucleo-cytoplasmic distribution of SAP18 reveals its dual function in splicing regulation and heat-stress response in Arabidopsis.Plant communications · 2025Article
- Programmed cell death regulator BAP2 is required for IRE1-mediated unfolded protein response in Arabidopsis.Nature communications · 2024Article
- Article
- Understanding AP2/ERF Transcription Factor Responses and Tolerance to Various Abiotic Stresses in Plants: A Comprehensive Review.International journal of molecular sciences · 2024Review
- BASIC PENTACYSTEINE1 regulatesFrontiers in plant science · 2024Article
- Histone Deacetylase Complex 1 and histone 1 epigenetically moderate stress responsiveness of Arabidopsis thaliana seedlings.The New phytologist · 2024Article
- Plant responses to abiotic stress regulated by histone acetylation.Frontiers in plant science · 2024Review
- The ethylene-responsive transcription factor PpERF9 represses PpRAP2.4 and PpMYB114 via histone deacetylation to inhibit anthocyanin biosynthesis in pear.The Plant cell · 2023Article
- Salicylic Acid Treatment and Its Effect on Seed Yield and Seed Molecular Composition ofInternational journal of molecular sciences · 2023Article
- Advances of Apetala2/Ethylene Response Factors in Regulating Development and Stress Response in Maize.International journal of molecular sciences · 2023Review
- Strategic optimization of conditions for the solubilization of GST-tagged amphipathic helix-containing ciliary proteins overexpressed as inclusion bodies in E. coli.Microbial cell factories · 2022Article
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2022Article
- Interaction Analysis between theInternational journal of molecular sciences · 2022Article
- SlERF.F12 modulates the transition to ripening in tomato fruit by recruiting the co-repressor TOPLESS and histone deacetylases to repress key ripening genes.The Plant cell · 2022Article
- Article
- The EAR Motif in thePlants (Basel, Switzerland) · 2021Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In yeast and mammalian systems, it is well established that transcriptional down-regulation by DNA-binding repressors involves core histone deacetylation, mediated by their interaction within a complex containing histone deacetylase (e.g. HDA1), as well as various other proteins (e.g. SIN3, SAP18, SAP30, and RbAp46). Here we identify that a Arabidopsis thaliana gene related in sequence to SAP18, designated AtSAP18, functions in transcription regulation in plants subjected to salt stress. The AtSAP18 loss- of-function mutant is more sensitive to NaCl, and is impaired in chlorophyll synthesis as compared to the wild-type. Using GST pull-down, two-hybrid, and transient transcription assays, we have characterized SAP18 and HDA1 orthologues and provide evidence that SAP18 and HDA1 function as transcriptional repressors. We further demonstrate that they associate with Ethylene-Responsive Element binding Factors (ERFs) to create a hormone-sensitive multimeric repressor complex under conditions of environmental stress. Our results indicate that AtSAP18 functions to link the HDA complex to transcriptional repressors that are bound to chromatin in a sequence-specific manner, thereby providing the specificity of signal transduction accompanying transcriptional repression under stress conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.