ArticleJournal of human genetics2006
Expression of the Snurf-Snrpn IC transcript in the oocyte and its putative role in the imprinting establishment of the mouse 7C imprinting domain.
Article in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome.Nature communications · 2025Article
- Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing.Cell genomics · 2025Article
- Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome.Research square · 2024Article
- Endocrine features of Prader-Willi syndrome: a narrative review focusing on genotype-phenotype correlation.Frontiers in endocrinology · 2024Review
- A mouse model of Angelman syndrome imprinting defects.Human molecular genetics · 2019Article
- Angelman syndrome imprinting center encodes a transcriptional promoter.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- New insights into establishment and maintenance of DNA methylation imprints in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Genomic imprinting: recognition and marking of imprinted loci.Current opinion in genetics & development · 2012Review
- Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.Frontiers in genetics · 2012Article
- Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.PLoS genetics · 2011Article
- Expression of SNURF-SNRPN upstream transcripts and epigenetic regulatory genes during human spermatogenesis.European journal of human genetics : EJHG · 2009Article
- Protein-binding elements establish in the oocyte the primary imprint of the Prader-Willi/Angelman syndromes domain.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transcription is required for establishment of germline methylation marks at imprinted genes.Genes & development · 2009Article
- Analysis of the Prader-Willi syndrome chromosome region using quantitative microsphere hybridization (QMH) array.American journal of medical genetics. Part A · 2008Article
- A targeted deletion upstream of Snrpn does not result in an imprinting defect.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human chromosome 15q11-q13, or mouse chromosome 7C, is an imprinting domain controlled by bipartite imprinting centers (ICs): Prader-Willi syndrome (PWS)-IC and Angelman syndrome (AS)-IC. PWS-IC functions to maintain the paternal epigenotype on the paternal chromosome in somatic cells, while AS-IC plays a role in the establishment of the maternal epigenetic mark at PWS-IC in the female germline or early embryos. Several alternative exons and promoters of Snurf-Snrpn (SNRPN upstream reading frame-small nuclear ribonucleoprotein polypeptide N) are expressed as "IC transcripts". Previous studies have shown that IC-transcript expression is restricted to the brain. We studied expression of the mouse IC-transcript in tissues including brain and oocytes as well as in cultured neurons and glia cells by RT-PCR and by in situ hybridization (ISH) in oocytes. The IC transcript was strongly expressed in brain (especially in neurons) and ovary (especially in oocytes and granulosa cells), while no expression was found in other tissues. This was confirmed by quantitative analysis and ISH. Expression levels in the brain were 7-fold higher compared to those in ovaries. ISH signals were observed in oocytes and granulosa cells of the secondary and developing follicles. These findings, together with previous data, suggest that the IC transcript may be associated with the establishment of PWS-IC methylation on the maternal chromosome as an AS-IC cis-acting element.
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