ArticleInfection and immunity2006
Entamoeba histolytica infection in children and protection from subsequent amebiasis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 192 citations in OpenAlex.
- Review
- Prevalence of Cryptosporidium, Giardia, and Entamoeba histolytica in the School-Aged Children of Forcibly Displaced Myanmar Nationals in Bangladesh.The American journal of tropical medicine and hygiene · 2025Article
- Selected Protective Mechanisms of Human Milk Against Intestinal Protozoal Infections in Infants.Current issues in molecular biology · 2025Review
- Metronidazole Suspension for Paediatric Use in Developing Countries: Formulation, Quality, and Stability.Pharmaceutics · 2025Article
- Clinical Outcomes of Liver Abscesses in Adults: A 10-Year Experience at a Tertiary Care Center in Northern India.Cureus · 2024Article
- Amebiasis as a sexually transmitted infection: A re-emerging health problem in developed countries.Global health & medicine · 2023Review
- Sex Difference in Amebiasis.Current topics in microbiology and immunology · 2023Article
- Review
- Exploratory toxicology studies of 2,3-substituted imidazo[1,2-Toxicology research · 2022Article
- Prevalence and associated risk factors ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Article
- Host Protective Mechanisms to Intestinal Amebiasis.Trends in parasitology · 2021Review
- Optimizing a Multi-Component IntranasalFrontiers in immunology · 2021Article
- Antigenic membrane proteins of virulent variant ofPathogens and global health · 2020Article
- Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.Frontiers in cellular and infection microbiology · 2020Review
- Entamoeba histolytica infection in humans, chimpanzees and baboons in the Greater Gombe Ecosystem, Tanzania.Parasitology · 2019Article
- Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children.Frontiers in immunology · 2019Article
- Article
- Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The contribution of amebiasis to the burden of diarrheal disease in children and the degree to which immunity is acquired from natural infection were assessed in a 4-year prospective observational study of 289 preschool children in an urban slum in Dhaka, Bangladesh. Entamoeba histolytica infection was detected at least once in 80%, and repeat infection in 53%, of the children who completed 4 years of observation. Annually there were 0.09 episodes/child of E. histolytica-associated diarrhea and 0.03 episodes/child of E. histolytica-associated dysentery. Fecal immunoglobulin A (IgA) anti-parasite Gal/GalNAc lectin carbohydrate recognition domain (anti-CRD) was detected in 91% (183/202) of the children at least once and was associated with a lower incidence of infection and disease. We concluded that amebiasis was a substantial burden on the overall health of the cohort children. Protection from amebiasis was associated with a stool anti-CRD IgA response. The challenge of producing an effective vaccine will be to improve upon naturally acquired immunity, which does not provide absolute protection from reinfection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.