ReviewChest2006
Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines.
Review in Chest, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Codeine versus placebo for chronic cough in children.The Cochrane database of systematic reviews · 2016Pooled it
- Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines.Chest · 2006Guideline
- Comparison of Jinzhen oral liquid and ambroxol hydrochloride and clenbuterol hydrochloride oral solution in the treatment of acute bronchitis in children: A multicenter, non-inferiority, prospective, randomized controlled trial.Acta pharmaceutica Sinica. B · 2024Trial
- Evaluation of the effects of food on levodropropizine controlled-release tablet and its pharmacokinetic profile in comparison to that of immediate-release tablet.Drug design, development and therapy · 2018Trial
- Cloperastine in paediatric and adult cough management: a historical narrative review.Drugs in context · 2026Review
- Article
- A Second Drug Binding Site in P2X3.bioRxiv : the preprint server for biology · 2024Article
- Efficacy and Safety of GHX02 in the Treatment of Acute Bronchitis and Acute Exacerbation of Chronic Bronchitis: A Phase Ⅱ, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial.Frontiers in pharmacology · 2021Article
- Cough Remedies for Children and Adolescents: Current and Future Perspectives.Paediatric drugs · 2020Article
- Review
- Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice.Pediatric allergy, immunology, and pulmonology · 2020Review
- Bronchiectasis and cough: An old relationship in need of renewed attention.Pulmonary pharmacology & therapeutics · 2019Review
- Immunity-targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2019Review
- Bronchodilators, Antibiotics, and Oral Corticosteroids Use in Primary Care for Children With Cough.Global pediatric health · 2019Article
- Clinical Practice Guidelines for Diagnosis and Management of Cough-Chinese Thoracic Society (CTS) Asthma Consortium.Journal of thoracic disease · 2018Review
- Soothing Properties of Glycerol in Cough Syrups for Acute Cough Due to Common Cold.Pharmacy (Basel, Switzerland) · 2017Review
- Prescription practice of antihistamines for acute upper respiratory tract infections in pediatric patients in a local emergency department in Hong Kong.World journal of emergency medicine · 2017Article
- Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections.Multidisciplinary respiratory medicine · 2017Review
- Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Cough: impact, beliefs, and expectations from a national survey.Multidisciplinary respiratory medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundCough-suppressant therapy, previously termed nonspecific antitussive therapy, incorporates the use of pharmacologic agents with mucolytic effects and/or inhibitory effects on the cough reflex itself. The intent of this type of therapy is to reduce the frequency and/or intensity of coughing on a short-term basis.
methodsData for this review were obtained from several National Library of Medicine (PubMed) searches (from 1960 to 2004), which were performed between May and September 2004, of the literature published in the English language, limited to human studies, using combinations of the search terms "cough," "double-blind placebo-controlled," "antitussive," "mucolytic," "cough clearance," "common cold," "protussive," "guaifenesin," "glycerol," and "zinc."
resultsMucolytic agents are not consistently effective in ameliorating cough in patients with bronchitis, although they may be of benefit to this population in other ways. Peripheral and central antitussive agents can be useful in patients with chronic bronchitis, but can have little efficacy in patients with cough due to upper respiratory infection. Some protussive agents are effective in increasing cough clearance, but their long-term effectiveness has not been established. DNase is not effective as a protussive agent in patients with cystic fibrosis. Inhaled mannitol is acutely effective in this patient population, but its therapeutic potential must be investigated further.
conclusionsThese findings suggest that suppressant therapy is most effective when used for the short-term reduction of coughing. Relatively few drugs are effective as cough suppressants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.