ArticleMolecular and cellular biology2006
Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Structural and Biophysical Investigation of the Key Hotspots on the Surface of Epstein-Barr Nuclear Antigen 1 Essential for DNA Recognition and Pathogenesis.Frontiers in molecular biosciences · 2021Article
- Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ.Genes & development · 2015Article
- Article
- Identification of properties of the Kaposi's sarcoma-associated herpesvirus latent origin of replication that are essential for the efficient establishment and maintenance of intact plasmids.Journal of virology · 2014Article
- A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.The Journal of biological chemistry · 2014Article
- Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus.Viruses · 2013Review
- Replication of Epstein-Barr viral DNA.Cold Spring Harbor perspectives in biology · 2013Review
- Differential chromatin structure encompassing replication origins in transformed and normal cells.Genes & cancer · 2012Article
- Article
- Tegument protein control of latent herpesvirus establishment and animation.Herpesviridae · 2011Article
- Development of drugs for Epstein-Barr virus using high-throughput in silico virtual screening.Expert opinion on drug discovery · 2010Article
- Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability.DNA repair · 2010Article
- Genome-wide analysis of host-chromosome binding sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1).Virology journal · 2010Article
- CTCF prevents the epigenetic drift of EBV latency promoter Qp.PLoS pathogens · 2010Article
- Regulation of Epstein-Barr virus origin of plasmid replication (OriP) by the S-phase checkpoint kinase Chk2.Journal of virology · 2010Article
- Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.PloS one · 2010Article
- Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation.Nucleic acids research · 2010Article
- Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function.The Journal of general virology · 2009Article
- Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We developed a mammalian plasmid replicon with a formerly uncharacterized origin of DNA synthesis, 8xRep*. 8xRep* functions efficiently to support once-per-cell-cycle synthesis of plasmid DNA which initiates within Rep*. By characterizing Rep*'s requirements for acting as an origin, we have uncovered several striking properties it shares with DS, the only other well-characterized, licensed, mammalian plasmid origin of DNA synthesis. Rep* contains a pair of previously unrecognized Epstein-Barr nuclear antigen 1 (EBNA1)-binding sites that are both necessary and sufficient in cis for its origin activity. These sites have an essential 21-bp center-to-center spacing, are bent by EBNA1, and recruit the origin recognition complex. The properties shared between DS and Rep* define cis and trans characteristics of a mammalian, extrachromosomal replicon. The role of EBNA1 likely reflects its evolution from cellular factors involved in the assembly of the initiation machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.