ArticleMolecular and cellular biology2006
Study of long-distance functional interactions between Su(Hw) insulators that can regulate enhancer-promoter communication in Drosophila melanogaster.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Impact of Interactions between Su(Hw)-Dependent Insulators on the Transvection Effect in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2024Article
- Enhancer Function in the 3D Genome.Genes · 2023Review
- Mechanisms of Interaction between Enhancers and Promoters in ThreeInternational journal of molecular sciences · 2023Review
- Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals andFrontiers in genetics · 2022Review
- The free-energy cost of interaction between DNA loops.Scientific reports · 2017Article
- Effect of Interaction between Chromatin Loops on Cell-to-Cell Variability in Gene Expression.PLoS computational biology · 2016Article
- Chromatin loops as allosteric modulators of enhancer-promoter interactions.PLoS computational biology · 2014Article
- Transcription through enhancers suppresses their activity in Drosophila.Epigenetics & chromatin · 2013Article
- Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function.PLoS genetics · 2013Article
- GATA simple sequence repeats function as enhancer blocker boundaries.Nature communications · 2013Article
- A role for insulator elements in the regulation of gene expression response to hypoxia.Nucleic acids research · 2012Article
- Drosophila errantiviruses.Mobile genetic elements · 2012Article
- Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors.Human gene therapy · 2011Review
- Roles of DNA looping in enhancer-blocking activity.Biophysical journal · 2011Article
- Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure.Nucleic acids research · 2010Article
- Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- Enhancer-promoter communication is regulated by insulator pairing in a Drosophila model bigenic locus.Molecular and cellular biology · 2008Article
- Functional interaction between the Fab-7 and Fab-8 boundaries and the upstream promoter region in the Drosophila Abd-B gene.Molecular and cellular biology · 2008Article
- Red flag on the white reporter: a versatile insulator abuts the white gene in Drosophila and is omnipresent in mini-white constructs.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Su(Hw) insulator found in the gypsy retrotransposon is the most potent enhancer blocker in Drosophila melanogaster. However, two such insulators in tandem do not prevent enhancer-promoter communication, apparently because of their pairing interaction that results in mutual neutralization. Furthering our studies of the role of insulators in the control of gene expression, here we present a functional analysis of a large set of transgenic constructs with various arrangements of regulatory elements, including two or three insulators. We demonstrate that their interplay can have quite different outcomes depending on the order of and distance between elements. Thus, insulators can interact with each other over considerable distances, across interposed enhancers or promoters and coding sequences, whereby enhancer blocking may be attenuated, cancelled, or restored. Some inferences concerning the possible modes of insulator action are made from collating the new data and the relevant literature, with tentative schemes illustrating the regulatory situations in particular model constructs.
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