Evidence map›Paper›PMID 16428430›Full record

ArticleJournal of bacteriology2006

The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit.

A E Sikora, R Zielke, K Datta, J R Maddock

Abstract read
In one paragraph

Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  7. The universally conserved prokaryotic GTPases.Microbiology and molecular biology reviews : MMBR · 2011
    Review
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  12. Article
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  15. Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A E SikoraDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109-1048, USA.
R Zielke
K Datta
J R Maddock

Funding

Characterization of the Vibrio harveyi CgtA proteinR03TW006001 · FIC · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MADDOCK, JANINE R. · 2002 to 2004
$121k
FIC NIH HHS R03 TW006001FIC NIH HHS TW006001
6 · The paper itself

Abstract

It was previously reported that unlike the other obg/cgtA GTPases, the Vibrio harveyi cgtAV is not essential. Here we show that cgtAV was not disrupted in these studies and is, in fact, essential for viability. Depletion of CgtAV did not result in cell elongation. CgtAV is associated with the large ribosomal particle. In light of our results, we predict that the V. harveyi CgtAV protein plays a similar essential role to that seen for Obg/CgtA proteins in other bacteria.

Indexed as

Bacterial ProteinsGTP-Binding ProteinsGTP PhosphohydrolasesMonomeric GTP-Binding ProteinsRibosomal ProteinsVibrioBacterial ProteinsCgtA protein, bacteriaGTP-Binding ProteinsGTP PhosphohydrolasesMonomeric GTP-Binding Proteinsribosomal protein L11Ribosomal Proteins

Identifiers

PMID16428430
PMCPMC1347350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.