ArticleJournal of bacteriology2006
The Fnr regulon of Bacillus subtilis.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 89 citations in OpenAlex.
- Simultaneous measurements of translation rate and transcriptome uncovers linked regulation within an active bacterial cell population.Science advances · 2026Article
- Carbon monoxide-driven proton respiration enables facultative anaerobes to survive electron acceptor limitation.The ISME journal · 2026Article
- From genes to function: regulation, maturation, and evolution of cytochromeApplied and environmental microbiology · 2025Review
- Microaerobic conditions enhance laccase production from Rheinheimera sp. in an economical medium.Archives of microbiology · 2022Article
- Bacterial approaches to sensing and responding to respiration and respiration metabolites.Molecular microbiology · 2021Review
- Implication of a Key Region of SixInternational journal of molecular sciences · 2021Article
- Transcriptional and Post-transcriptional Control of the Nitrate Respiration in Bacteria.Frontiers in molecular biosciences · 2021Review
- The Role of Fnr Paralogs in Controlling Anaerobic Metabolism in the Diazotroph Paenibacillus polymyxa WLY78.Applied and environmental microbiology · 2020Article
- Towards the Anaerobic Production of Surfactin UsingFrontiers in bioengineering and biotechnology · 2020Article
- Virulence and Metabolism.Microbiology spectrum · 2019Review
- The RicAFT (YmcA-YlbF-YaaT) complex carries two [4Fe-4S]Molecular microbiology · 2017Article
- Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45.Scientific reports · 2017Article
- Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium.PLoS genetics · 2015Article
- Hyperphosphorylation of DegU cancels CcpA-dependent catabolite repression of rocG in Bacillus subtilis.BMC microbiology · 2015Article
- Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.Journal of bacteriology · 2015Article
- Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses.The Journal of biological chemistry · 2014Article
- Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response.Applied and environmental microbiology · 2014Article
- Bacillus cereus cell response upon exposure to acid environment: toward the identification of potential biomarkers.Frontiers in microbiology · 2013Review
- YjcC, a c-di-GMP phosphodiesterase protein, regulates the oxidative stress response and virulence of Klebsiella pneumoniae CG43.PloS one · 2013Article
- Bacillus cereus Fnr binds a [4Fe-4S] cluster and forms a ternary complex with ResD and PlcR.BMC microbiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bacillus subtilis transcriptional regulator Fnr is an integral part of the regulatory cascade required for the adaptation of the bacterium to low oxygen tension. The B. subtilis Fnr regulon was defined via transcriptomic analysis in combination with bioinformatic-based binding site prediction. Four distinct groups of Fnr-dependent genes were observed. Group 1 genes (narKfnr, narGHJI, and arfM) are generally induced by Fnr under anaerobic conditions. All corresponding promoters contain an essential Fnr-binding site centered -41.5/-40.5 bp upstream of the transcriptional start point, suggesting their induction by direct Fnr interaction. Group 2 genes (alsSD, ldh lctP, ywcJ, and cydABCD) are characterized by anaerobic repression in the presence of nitrate. Mutational analysis of the Fnr-binding sites found in three of the corresponding promoters excluded their function in Fnr-mediated repression. Genetic evidence showing that group 2 genes are anaerobically repressed by nitrate reductase formation was accumulated. A possible role of the redox regulator YdiH in the regulation of group 2 genes was initially investigated. Group 3 genes are characterized by their Fnr-dependent activation in the presence of nitrate and the lack of an Fnr-binding site in their promoters. The analysis of Group 3 gene transcription (ykuNOP and ydbN) indicated that Fnr induces nitrate reductase production, which leads to the formation of the regulatory compound nitrite from nitrate. Finally, the group 4 operon acoABCL, lacking an Fnr-binding site, requires Fnr-dependent nitrate reductase formation for its general anaerobic induction. A regulatory model for the observed complex Fnr-mediated gene expression was deduced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.