ArticleJournal of bacteriology2006
Two DNA invertases contribute to flagellar phase variation in Salmonella enterica serovar Typhimurium strain LT2.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 64 citations in OpenAlex.
- Adsorption of phage T2 is inhibited due to inversion of cryptic prophage DNA by the serine recombinase PinQ.Nucleic acids research · 2025Article
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- Recruitment of Mobile Genetic Elements for Diverse Cellular Functions in Prokaryotes.Frontiers in molecular biosciences · 2022Review
- Antimicrobial resistance patterns, virulence gene profiles, and genetic diversity ofIranian journal of basic medical sciences · 2021Article
- Prevalence and Distribution Characteristics ofInfection and drug resistance · 2020Article
- Recombination of the Phase-VariableJournal of bacteriology · 2019Article
- Antimicrobial resistance, biofilm synthesis and virulence genes in Salmonella isolated from pigs bred on intensive farms.Italian journal of food safety · 2018Article
- Genome-wide detection of conservative site-specific recombination in bacteria.PLoS genetics · 2018Article
- Review
- AProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Bacterial iprA Gene Is Conserved across Enterobacteriaceae, Is Involved in Oxidative Stress Resistance, and Influences Gene Expression in Salmonella enterica Serovar Typhimurium.Journal of bacteriology · 2016Article
- The O-Antigen Capsule of Salmonella enterica Serovar Typhimurium Facilitates Serum Resistance and Surface Expression of FliC.Infection and immunity · 2015Article
- Extensive genetic variability linked to IS26 insertions in the fljB promoter region of atypical monophasic variants of Salmonella enterica serovar Typhimurium.Applied and environmental microbiology · 2015Article
- Site-specific DNA Inversion by Serine Recombinases.Microbiology spectrum · 2015Article
- Systematic identification and quantification of phase variation in commensal and pathogenic Escherichia coli.Genome medicine · 2014Article
- Characteristics of Salmonella enterica serovar 4,[5],12:i:- as a monophasic variant of serovar Typhimurium.PloS one · 2014Article
- Article
- Molecular identification in monophasic and nonmotile variants of Salmonella enterica serovar Typhimurium.MicrobiologyOpen · 2012Article
- Effect of iacP mutation on flagellar phase variation in Salmonella enterica serovar typhimurium strain UK-1.Journal of bacteriology · 2012Article
- Receptor diversity and host interaction of bacteriophages infecting Salmonella enterica serovar Typhimurium.PloS one · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serovar Typhimurium strain LT2 possesses two nonallelic structural genes, fliC and fljB, for flagellin, the component protein of flagellar filaments. Flagellar phase variation occurs by alternative expression of these two genes. This is controlled by the inversion of a DNA segment, called the H segment, containing the fljB promoter. H inversion occurs by site-specific recombination between inverted repetitious sequences flanking the H segment. This recombination has been shown in vivo and in vitro to be mediated by a DNA invertase, Hin, whose gene is located within the H segment. However, a search of the complete genomic sequence revealed that LT2 possesses another DNA invertase gene that is located adjacent to another invertible DNA segment within a resident prophage, Fels-2. Here, we named this gene fin. We constructed hin and fin disruption mutants from LT2 and examined their phase variation abilities. The hin disruption mutant could still undergo flagellar phase variation, indicating that Hin is not the sole DNA invertase responsible for phase variation. Although the fin disruption mutant could undergo phase variation, fin hin double mutants could not. These results clearly indicate that both Hin and Fin contribute to flagellar phase variation in LT2. We further showed that a phase-stable serovar, serovar Abortusequi, which is known to possess a naturally occurring hin mutation, lacks Fels-2, which ensures the phase stability in this serovar.
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