ArticleJournal of bacteriology2006
Arginine-dependent gene regulation via the ArgR repressor is species specific in chlamydia.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023Review
- Article
- GrgA overexpression inhibits Chlamydia trachomatis growth through sigmaMicrobial pathogenesis · 2021Article
- The Repressor Function of theJournal of bacteriology · 2020Article
- Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation inFrontiers in cellular and infection microbiology · 2017Review
- Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae.Journal of bacteriology · 2014Review
- Transcription factors and genetic circuits orchestrating the complex, multilayered response of Clostridium acetobutylicum to butanol and butyrate stress.BMC systems biology · 2013Article
- The early gene product EUO is a transcriptional repressor that selectively regulates promoters of Chlamydia late genes.Molecular microbiology · 2012Article
- Identification and functional analysis of CT069 as a novel transcriptional regulator in Chlamydia.Journal of bacteriology · 2011Article
- Independent inactivation of arginine decarboxylase genes by nonsense and missense mutations led to pseudogene formation in Chlamydia trachomatis serovar L2 and D strains.BMC evolutionary biology · 2009Article
- SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.Journal of bacteriology · 2009Article
- Outer and inner membrane proteins compose an arginine-agmatine exchange system in Chlamydophila pneumoniae.Journal of bacteriology · 2008Article
- Characterization of an acid-dependent arginine decarboxylase enzyme from Chlamydophila pneumoniae.Journal of bacteriology · 2007Article
- An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice.Nucleic acids research · 2007Article
- Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Some, but not all, Chlamydia spp. are predicted to encode a homolog of ArgR, a master regulatory molecule that modulates arginine biosynthesis and catabolism in bacteria in response to intracellular arginine levels. While genes for arginine biosynthesis are apparently missing in Chlamydia, a putative arginine transport system encoded by glnP, glnQ, and artJ is present. We found that recombinant Chlamydia pneumoniae ArgR functions as an arginine-dependent aporepressor that bound specifically to operator sequences upstream of the glnPQ operon. ArgR was able to repress transcription in a promoter-specific manner that was dependent on the concentration of the corepressor l-arginine. We were able to locate ArgR operators upstream of glnPQ in C. pneumoniae and Chlamydophila caviae but not Chlamydia trachomatis, which corresponded to the predicted presence or absence of ArgR in these chlamydial species. Our findings indicate that only some members of the family Chlamydiaceae have an arginine-responsive mechanism of gene regulation that is predicted to control arginine uptake from the host cell. This is the first study to directly demonstrate a species-specific mechanism of transcriptional regulation in Chlamydia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.