ArticleBMJ (Clinical research ed.)2006
Chronic stress at work and the metabolic syndrome: prospective study.
Article in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 347 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
347 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,059 citations in OpenAlex.
- Maternal psychological stress during pregnancy and newborn telomere length: a systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- The relationship between minority stress and biological outcomes: A systematic review.Journal of behavioral medicine · 2020Pooled it
- Global, regional and time-trend prevalence of central obesity: a systematic review and meta-analysis of 13.2 million subjects.European journal of epidemiology · 2020Pooled it
- Effects of a laughter program on body weight and mental health among Japanese people with metabolic syndrome risk factors: a randomized controlled trial.BMC geriatrics · 2022Trial
- Yoga complemented cognitive behavioral therapy on job burnout among teachers of children with autism spectrum disorders.Medicine · 2021Trial
- The effect of active occupational stress management on psychosocial and physiological wellbeing: a pilot study.BMC medical informatics and decision making · 2020Trial
- IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women.The Journal of clinical endocrinology and metabolism · 2020Trial
- A pilot randomised trial comparing a mindfulness-based stress reduction course, a locally-developed stress reduction intervention and a waiting list control group in a real-life municipal health care setting.BMC public health · 2020Trial
- Effect of nutritive and non-nutritive sweeteners on hemodynamic responses to acute stress: a randomized crossover trial in healthy women.Nutrition & diabetes · 2020Trial
- Taking a Stand for Office-Based Workers' Mental Health: The Return of the Microbreak.Frontiers in public health · 2020Trial
- Mindfulness on-the-go: Effects of a mindfulness meditation app on work stress and well-being.Journal of occupational health psychology · 2019Trial
- Trial
- Chronic Stress and Cardiovascular Health: The MESA and MASALA Studies.American journal of preventive medicine · 2026Article
- Workplace stress and healthy aging: assessment strategies, research hypotheses, and pilot insights from the Semmelweis study.GeroScience · 2026Review
- Technostress and Insulin Resistance Risk: A Cross-Sectional Analysis of 104,175 Spanish Workers Using TyG, TyG-BMI, METS-IR, and SPISE Indices.Medical sciences (Basel, Switzerland) · 2026Article
- Working out of necessity: how job lock shapes health for older workers.The Gerontologist · 2026Article
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience.Translational psychiatry · 2026Article
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Musculoskeletal complaints, working conditions, and job satisfaction among Dutch orthodontists.European journal of orthodontics · 2026Article
287 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo investigate the association between stress at work and the metabolic syndrome. [table: see text].
designProspective cohort study investigating the association between work stress and the metabolic syndrome.
participants10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall II study); follow-up was an average of 14 years.
main outcome measuresWork stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1997-9.
resultsA dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85).
conclusionsStress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.