ArticleComparative biochemistry and physiology. Part B, Biochemistry & molecular biology2006
Molecular cloning and characterization of crustacean type-one dopamine receptors: D1alphaPan and D1betaPan.
Article in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Identification of putative amine receptor complement in the eyestalk of the crayfish, Procambarus clarkii.Invertebrate neuroscience : IN · 2019Article
- Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis).PloS one · 2018Article
- Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan.Scientific reports · 2017Article
- Deep sequencing of transcriptomes from the nervous systems of two decapod crustaceans to characterize genes important for neural circuit function and modulation.BMC genomics · 2016Article
- Article
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
- Characterization of an invertebrate-type dopamine receptor of the American cockroach, Periplaneta americana.International journal of molecular sciences · 2014Article
- Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR.BMC neuroscience · 2013Article
- Review
- Tonic dopamine induces persistent changes in the transient potassium current through translational regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dopamine-induced oscillations of the pyloric pacemaker neuron rely on release of calcium from intracellular stores.Journal of neurophysiology · 2011Article
- Article
- Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.Journal of neurophysiology · 2010Article
- D(2) receptors receive paracrine neurotransmission and are consistently targeted to a subset of synaptic structures in an identified neuron of the crustacean stomatogastric nervous system.The Journal of comparative neurology · 2010Article
- Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion.Journal of neurochemistry · 2008Article
- Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dopamine (DA) differentially modulates identified neurons in the crustacean stomatogastric nervous system (STNS). While the electrophysiological actions of DA have been well characterized, little is known about the dopaminergic transduction cascades operating in this system. As a first step toward illuminating the molecular underpinnings of dopaminergic signal transduction in the crustacean STNS, we have cloned and characterized two type-one DA receptors (DARs) from the spiny lobster (Panulirus interruptus): D(1alphaPan) and D(1betaPan). We found that the structure and function of these arthropod DARs are well conserved across species. Using a heterologous expression system, we determined that DA, but not serotonin, octopamine, tyramine or histamine activates these receptors. When stably expressed in HEK cells, the D(1alphaPan) receptor couples with Gs, and DA elicits an increase in [cAMP]. The D(1betaPan) receptor responds to DA with a net increase in [cAMP] that is mediated by Gs and Gz.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.