ArticleImmunome research2006
Modeling the bound conformation of Pemphigus vulgaris-associated peptides to MHC Class II DR and DQ alleles.
Article in Immunome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 117 citations in OpenAlex.
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- Pathogenic selection promotes adaptive immune variations against serious bottlenecks in early invasions of bullfrogs.iScience · 2023Article
- Habitat fragmentation in the Brazilian Atlantic Forest is associated with erosion of frog immunogenetic diversity and increased fungal infections.Immunogenetics · 2022Article
- Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?Frontiers in immunology · 2020Review
- Polymorphism in the major histocompatibility complex (MHC class II B) genes of the Rufous-backed Bunting (PeerJ · 2017Article
- Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation.Proceedings. Biological sciences · 2015Article
- Identification and characterization of major histocompatibility complex class IIB alleles from three species of European ranid frogs.Molecular biology research communications · 2014Article
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- Evolutionary history of black grouse major histocompatibility complex class IIB genes revealed through single locus sequence-based genotyping.BMC genetics · 2013Article
- Social and extra-pair mating in relation to major histocompatibility complex variation in common yellowthroats.Proceedings. Biological sciences · 2012Article
- MHC genotypes associate with resistance to a frog-killing fungus.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Reduced MHC and neutral variation in the Galápagos hawk, an island endemic.BMC evolutionary biology · 2011Article
- Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes.PloS one · 2010Article
- Selection, trans-species polymorphism, and locus identification of major histocompatibility complex class IIβ alleles of New World ranid frogs.Immunogenetics · 2010Article
- Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously.Clinical and experimental immunology · 2010Article
- pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes.Immunome research · 2010Article
- Balancing selection, sexual selection and geographic structure in MHC genes of Great Snipe.Genetica · 2010Article
- Evolutionary analysis and expression profiling of zebra finch immune genes.Genome biology and evolution · 2010Article
- Isolation and characterization of major histocompatibility complex (MHC) class II B genes in the Barn owl (Aves: Tyto alba).Immunogenetics · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPemphigus vulgaris (PV) is a severe autoimmune blistering disorder characterized by the presence of pathogenic autoantibodies directed against desmoglein-3 (Dsg3), involving specific DR4 and DR6 alleles in Caucasians and DQ5 allele in Asians. The development of sequence-based predictive algorithms to identify potential Dsg3 epitopes has encountered limited success due to the paucity of PV-associated allele-specific peptides as training data.
resultsIn this work we constructed atomic models of ten PV associated, non-associated and protective alleles. Nine previously identified stimulatory Dsg3 peptides, Dsg3 96-112, Dsg3 191-205, Dsg3 206-220, Dsg3 252-266, Dsg3 342-356, Dsg3 380-394, Dsg3 763-777, Dsg3 810-824 and Dsg3 963-977, were docked into the binding groove of each model to analyze the structural aspects of allele-specific binding.
conclusionOur docking simulations are entirely consistent with functional data obtained from in vitro competitive binding assays and T cell proliferation studies in DR4 and DR6 PV patients. Our findings ascertain that DRB1*0402 plays a crucial role in the selection of specific self-peptides in DR4 PV. DRB1*0402 and DQB1*0503 do not necessarily share the same core residues, indicating that both alleles may have different binding specificities. In addition, our results lend credence to the hypothesis that the alleles DQB1*0201 and *0202 play a protective role by binding Dsg3 peptides with greater affinity than the susceptible alleles, allowing for efficient deletion of autoreactive T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.