ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2006
Upregulation of IFN-gamma receptor expression by proinflammatory cytokines influences IDO activation in epithelial cells.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
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- Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism.Nutrients · 2022Trial
- Targeting inflammation to influence mood following spinal cord injury: a randomized clinical trial.Journal of neuroinflammation · 2015Trial
- Mucosal Responses to Type II Interferon in IBD.Inflammatory bowel diseases · 2025Article
- Dysregulated placental expression of kynurenine pathway enzymes is associated with inflammation and depression in pregnancy.Brain, behavior, and immunity · 2024Article
- Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment.Molecular biology reports · 2023Review
- IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma.British journal of cancer · 2023Article
- Synergistic effect of IFN-γ and IL-1β on PD-L1 expression in hepatocellular carcinoma.Biochemistry and biophysics reports · 2022Article
- Modulation of the tumor micro-environment by CD8Current opinion in immunology · 2021Review
- Involvement of Kynurenine Metabolism in Bipolar Disorder: An Updated Review.Frontiers in psychiatry · 2021Review
- IDO Expression in Cancer: Different Compartment, Different Functionality?Frontiers in immunology · 2020Review
- The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression.Journal of neuroinflammation · 2019Article
- Human Oral Epithelial Cells Impair Bacteria-Mediated Maturation of Dendritic Cells and Render T Cells Unresponsive to Stimulation.Frontiers in immunology · 2019Article
- Article
- Cross-talk between TNF-α and IFN-γ signaling in induction of B7-H1 expression in hepatocellular carcinoma cells.Cancer immunology, immunotherapy : CII · 2018Article
- Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association withFrontiers in cellular and infection microbiology · 2018Article
- Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis.Oncology letters · 2017Article
- Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2016Article
- IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C.PloS one · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interferon-gamma (IFN-gamma) induces the enzyme indoleamine dioxygenase (IDO) in a variety of human cell types. Furthermore, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) synergistically increase IFN-induced IDO activity. Inasmuch as cytokines can upregulate cytokine receptor expression, one mechanism of cytokine synergy may be at the level of receptor expression. To test the hypothesis that this mechanism of IDO regulation is active in epithelial cells, HeLa cells were treated with IFN-gamma, TNF-alpha, or IL-1beta to determine optimal cytokine concentrations and time for maximal cytokine receptor expression. Flow cytometric analysis with antibodies to receptors for IFN-gamma, TNF-alpha, or IL-1beta indicated that each cytokine upregulated expression of the other cytokine receptors by 4 h, with maximal expression observed between 16 and 20 h after cytokine treatment. Furthermore, increases in IFN-gamma receptors (IFNGR) induced by IL-1beta were found to be dependent on NF-kappaB transactivation. To determine if increases in IFNGR expression alone contributes to synergistic IDO induction, cells were stimulated with IL-1beta to upregulate receptor expression, and the NF-kappaB concentration was allowed to return to basal levels. When treated with IFN-gamma, enhanced Stat1 signaling and IDO induction were still observed, indicating that increased cytokine receptor expression contributes to synergistic increases in IDO activity.
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