ArticleClinical and vaccine immunology : CVI2006
Detection of immunoglobulin G antibodies to Neospora caninum in humans: high seropositivity rates in patients who are infected by human immunodeficiency virus or have neurological disorders.
Article in Clinical and vaccine immunology : CVI, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 135 citations in OpenAlex.
- High occurrence of anti-Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2026Article
- Evidence of in Utero Anti-Microorganisms · 2026Article
- Molecular Detection of Toxoplasma gondii and Neospora caninum in Naturally Infected sheep, cow, and buffalo Milk.Acta parasitologica · 2025Article
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- Neospora caninum Inhibits Lewis Cancer and B16f10 Melanoma Lung Metastasis Development by Activating the Immune Response in Murine Models.Acta parasitologica · 2025Article
- Glycyrrhiza polysaccharide attenuatesFrontiers in veterinary science · 2025Article
- Molecular and serological prevalence rates of Neospora caninum infection in dogs from Jordan.Parasitology research · 2024Article
- Are genetically modified protozoa eligible for ATMP status? Concerning the legal categorization of an oncolytic protozoan drug candidate.Gene therapy · 2024Article
- Seroprevalence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- RNA sequencing reveals dynamic expression of lncRNAs and mRNAs in caprine endometrial epithelial cells induced by Neospora caninum infection.Parasites & vectors · 2022Article
- A survey on Apicomplexa protozoa in sheep slaughtered for human consumption.Parasitology research · 2022Article
- Occurrence of Toxoplasma gondii and Neospora caninum antibodies and risk factors in domiciliated dogs of Manaus, Amazonas, Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2022Article
- Seroepidemiology ofVeterinary medicine (Auckland, N.Z.) · 2022Article
- Seroprevalence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Raw meat based diet (RMBD) for household pets as potential door opener to parasitic load of domestic and urban environment. Revival of understated zoonotic hazards? A review.One health (Amsterdam, Netherlands) · 2021Review
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- Biosurveillance of Selected Pathogens with Zoonotic Potential in a Zoo.Pathogens (Basel, Switzerland) · 2021Article
- Detection of antibodies toFood and waterborne parasitology · 2021Article
- The Protective Role of TLR2 Mediates Impaired Autophagic Flux by Activating the mTOR Pathway DuringFrontiers in cellular and infection microbiology · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considering that little is known about the epidemiology of Neospora caninum infection in humans, particularly in populations with high Toxoplasma gondii infection rates, the present study aimed to investigate the presence of antibodies to N. caninum in T. gondii-seropositive and -seronegative individuals. A total of 256 serum samples divided into four groups (61 samples from human immunodeficiency virus [HIV]-positive patients, 50 samples from patients with neurological disorders, 91 samples from newborns, and 54 samples from healthy subjects) were assessed for N. caninum and T. gondii serologies by indirect fluorescent-antibody test, enzyme-linked immunosorbent assay, and immunoblotting (IB). Immunoglobulin G antibodies to N. caninum were predominantly detected in HIV-infected patients (38%) and patients with neurological disorders (18%), while newborns and healthy subjects showed lower seropositivity rates (5% and 6%, respectively). Seropositivity to N. caninum was significantly associated with seropositivity to T. gondii in both HIV-infected patients and patients with neurological disorders. Seroreactivity to N. caninum was confirmed by IB, with positive sera predominantly recognizing the 29-kDa antigen of N. caninum. The results of this study indicate the presence of N. caninum infection or exposure in humans, particularly in HIV-infected patients or patients with neurological disorders, who could have opportunistic and concurrent infections with T. gondii. These findings may bring a new concern for the unstable clinical health of HIV-infected patients and the actual role of N. caninum infection in immunocompromised patients.
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