ArticleWorld journal of gastroenterology2005
Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacter pylori infection.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 17 citations in OpenAlex.
- Analysis of the sensitization activity ofFrontiers in nutrition · 2024Article
- Helicobacter pylori: bacterial factors and the role of cytokines in the immune response.Current microbiology · 2010Article
- Persistent H. pylori colonization in early acquisition age of mice related with higher gastric sialylated Lewis x, IL-10, but lower interferon-γ expressions.Journal of biomedical science · 2009Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo measure the concentrations of chosen cytokines in the antrum mucosa depending on the kind of harmful pathogenic factors and to compare the concentrations with the values of controls without allergy and coexisting Helicobacter pylori (H pylori) infection.
methodsThe patients (97 children) were divided into three groups according to the data obtained from the case history, to the main cause of the disease and to the dominant clinical symptoms. Group I: children with food allergy (Fa); group II: children infected with H pylori; group III (control group): children with functional disorders of the alimentary tract (without Fa and Hp infection). H pylori infection was determined by the presence of anti-Hp antibodies in serum (ELISA method) and urease test performed during endoscopic examination. Cytokine concentration in homogenates of gastric mucosa was detected by ELISA method.
resultsThe IL-2 concentration in gastric mucosa bioptates was the highest in children with Hp infection (116.5+/-179.5 pg/mg of the protein) and Fa and Hp infection (98.1+/-101.0 pg/mg), while decreased in children with Fa (44.8+/-50.3 pg/mg) and controls (45.7+/-23.5 pg/mg). The lowest mean concentration of IFN-gamma was observed in children with Hp infection (18.9+/-16.4 pg/mg), with Fa and Hp infection (25.5+/-27.7 pg/mg), with Fa (40.6+/-39.7 pg/mg) and controls (49.9+/-33.4 pg/mg). The highest IL-4 concentrations were observed in children with Hp infection (35.3+/-52.8 pg/mg) and in children with Fa and Hp infection (37.2+/-51.7 pg/mg), while lower IL-4 concentration (23.6+/-35.8 pg/mg) was found in children with Fa compared to the controls (22.7+/-13.8 pg/mg). The analysis of IL-4 concentrations in children with Hp infection regarding the intensity of gastritis showed the highest value (62.2+/-61.2 pg/mg) in mild and moderate gastritis. The concentrations of IL-5 in the gastric mucosa of children with or without Fa did not differ significantly and were comparable to the control group. The highest mean IL-8 value was observed in Hp-infected children with or without Fa. The highest concentration of mucosal IL-10 was detected in children with Hp infection (79.3+/-41.2 pg/mg) and decreased in children with Fa and Hp infection (50.1+/-18.8 pg/mg) and in children with Fa (39.9+/-35.5 pg/mg). The intensity and activity of the inflammation did not affect IL-10 concentrations in the gastric mucosa. In children with Hp infection, TNF-alpha concentration was the highest (45.9+/-49.3 pg/mg) and in children with Fa and Hp infection was low (45.3+/-32.6 pg/mg), whereas decreased in children with Fa (21.7+/-34.2 pg/mg) and in controls (31.6+/-14.5 pg/mg).
conclusionThe morphological changes of the gastric mucosa in children with Hp infection are comparable to those in children with Fa and coexisting Hp infection. Cytokine concentration in children with Fa and Hp infection is significantly different in IFN-gamma, IL-2, IL-8, and TNF-alpha.
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