ReviewJournal of applied genetics2006
Mitochondrial DNA mutations in human neoplasia.
Review in Journal of applied genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Pooled it
- Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?Journal of biomedical science · 2010Pooled it
- Role of mitochondrial translation in modulating inflammatory disease outcome: Current knowledge and future perspectives.The Journal of biological chemistry · 2026Review
- Amination of Graphene Oxide Leads to Increased Cytotoxicity in Hepatocellular Carcinoma Cells.International journal of molecular sciences · 2020Article
- Review
- Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Identification of additional mitochondrial DNA mutations in canine mast cell tumours.Acta veterinaria Scandinavica · 2016Article
- Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival.Cancer informatics · 2015Article
- Article
- Mitochondrial dysfunction in cancer.Przeglad menopauzalny = Menopause review · 2014Review
- Opportunities and challenges for selected emerging technologies in cancer epidemiology: mitochondrial, epigenomic, metabolomic, and telomerase profiling.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Review
- Regulation of metastasis; mitochondrial DNA mutations have appeared on stage.Journal of bioenergetics and biomembranes · 2012Review
- Mitochondrial DNA 4977 bp Deletion in Chronic Cervicitis and Cervix Cancers.Balkan journal of medical genetics : BJMG · 2012Article
- Genetic insights into OXPHOS defect and its role in cancer.Biochimica et biophysica acta · 2011Review
- The role of the mitochondrial genome in ageing and carcinogenesis.Journal of aging research · 2011Article
- Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest.Journal of biomedical science · 2010Article
- Common mitochondrial polymorphisms as risk factor for endometrial cancer.International archives of medicine · 2009Article
- Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men.The Prostate · 2009Article
- Mitochondria and cancer.Virchows Archiv : an international journal of pathology · 2009Review
- Sequencing strategy for the whole mitochondrial genome resulting in high quality sequences.BMC genomics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many models of tumour formation have been put forth so far. In general they involve mutations in at least three elements within the cell: oncogenes, tumour suppressors and regulators of telomere replication. Recently numerous mutations in mitochondria have been found in many tumours, whereas they were absent in normal tissues from the same individual. The presence of mutations, of course, does not prove that they play a causative role in development of neoplastic lesions and progression; however, the key role played by mitochondria in both apoptosis and generation of DNA-damaging reactive oxygen species might indicate that the observed mutations contribute to tumour development. Recent experiments with nude mice have proven that mtDNA mutations are indeed responsible for tumour growth and exacerbated ROS production. This review describes mtDNA mutations in main types of human neoplasia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.