ArticleAJR. American journal of roentgenology2006
Carotid artery calcification on CT may independently predict stroke risk.
Article in AJR. American journal of roentgenology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Artificial Intelligence-assisted Diagnosis of Carotid Artery Calcifications on Panoramic Radiographs: A Meta-analysis.International dental journal · 2026Pooled it
- The relation of carotid calcium volume with carotid artery stenosis in symptomatic patients.AJNR. American journal of neuroradiology · 2011Trial
- Carotid plaque inflammation and calcification on somatostatin receptor PET/CT imaging predict stroke and major adverse cardiovascular events.European heart journal. Cardiovascular Imaging · 2026Article
- Side- and patient-based performance of a deep learning system based on the results of individual detection of carotid artery calcifications on panoramic radiographs.Imaging science in dentistry · 2026Article
- Ultra-high-resolution and dual-energy computed tomography of carotid artery plaques differentiate symptomatic and asymptomatic patients by novel volumetric analysis.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Incidence of ocular ischemic syndrome in patients with asymptomatic severe internal carotid artery stenosis.International ophthalmology · 2025Article
- Association between carotid plaque calcification and clinical outcomes of symptomatic cerebral small vessel disease.Frontiers in neurology · 2025Article
- Extracranial carotid plaque calcification and its association with risk factors for cerebrovascular events: insights from the ANTIQUE study.Frontiers in neurology · 2025Article
- Carotid atherosclerotic plaque microcalcification is independently associated with recurrent neurovascular events: A pilot study.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Opportunistic investigation of vascular calcification using 3-dimensional dental imaging.Imaging science in dentistry · 2024Article
- Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study.BMC neurology · 2024Article
- CACSNet for automatic robust classification and segmentation of carotid artery calcification on panoramic radiographs using a cascaded deep learning network.Scientific reports · 2024Article
- Atherosclerotic plaque features relevant to rupture-risk detected by clinical photon-counting CT ex vivo: a proof-of-concept study.European radiology experimental · 2024Article
- Cross-Sectional Validation of a Novel Computed Tomography-Based Carotid Mean Calcium Density Measurement.Journal of the American Heart Association · 2023Article
- Automated Detection of Cervical Carotid Artery Calcifications in Cone Beam Computed Tomographic Images Using Deep Convolutional Neural Networks.Diagnostics (Basel, Switzerland) · 2022Article
- SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events.AJNR. American journal of neuroradiology · 2022Article
- Imaging Approaches to the Diagnosis of Vascular Diseases.Current atherosclerosis reports · 2022Review
- Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes.International journal of hypertension · 2022Article
- A narrative review of exosomes in vascular calcification.Annals of translational medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of our study was to quantitatively evaluate calcified atherosclerotic burden in the cervical carotid arteries using MDCT to determine the relationship of scores with luminal stenosis and symptomatology. MATERIALS AND
methodsCalcium plaque volume was measured in 106 cervical carotid arteries (53 patients) using MDCT angiography. The study group included 32 asymptomatic patients (mean age, 70.2 +/- 8.7 [SD] years; 15 women, 17 men) and 21 patients with ischemic neurologic symptoms (69.6 +/- 12.9 years; eight women, 13 men). By vessel, there were 43 high-grade stenotic (> or = 60% by North American Symptomatic Carotid Endarterectomy Trial [NASCET] criteria), 15 moderate-grade stenotic (30-59%), and 44 mild-grade stenotic or normal (0-29%) vessels, with four excluded for prior carotid endarterectomy. Volume scores were calculated by summing the area of calcium in the common and extracranial internal carotid arteries on axial slices and multiplying by the slice increment.
resultsControlling for cardiovascular risk factors and luminal stenosis, we found that scores were significantly related to the occurrence of symptoms (p = 0.003). Even with patient age as a covariant, patients with high-grade stenosis had significantly higher scores than those without high-grade disease (p = 0.004). Moreover, quantitative burden was associated with luminal stenosis on adjusted multivariate analysis (p = 0.034). The specificity and positive predictive value for high-grade luminal narrowing were notably lower on individual vessel analysis than on total score analysis, likely secondary to variability in vascular remodeling.
conclusionCalcium scores in the cervical carotid arteries may represent an independent marker for luminal stenosis and ischemic symptoms. A prospective longitudinal study examining calcium levels and morbidity may be warranted to examine whether burden has a role in risk stratification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.