Evidence map›Paper›PMID 16423889›Full record

ReviewGut2006

Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis.

M Hummel, S Oeschger, T F E Barth, C Loddenkemper, S B Cogliatti, A Marx, H-H Wacker, A C Feller, H-W Bernd, M-L Hansmann and 2 more

Open access · greenAbstract readMulticenter StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  4. Gastric Mucosa-associated Lymphoid Tissue Lymphoma Mimicking Signet Ring Cell Carcinoma.The Korean journal of helicobacter and upper gastrointestinal research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

M HummelInstitute of Pathology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany. Michael.Hummel@charite.de
S Oeschger
T F E Barth
C Loddenkemper
S B Cogliatti
A Marx
H-H Wacker
A C Feller
H-W Bernd
M-L Hansmann
H Stein
P Möller
Charité - Universitätsmedizin Berlin · DEUniversity Hospital Frankfurt · DEUniversity Hospital Ulm · DEUniversity of Lübeck · DEKantonsspital St. Gallen · CHUniversitätsklinikum Würzburg · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsGastric mucosa associated lymphoid tissue lymphoma is a well defined B cell lymphoma yet often impossible to distinguish from severe chronic gastritis on morphological grounds alone. Therefore, it was suggested to use the clonality of the immunoglobulin (Ig) heavy chain (H) genes, as detected by polymerase chain reaction (PCR), as a decisive criterion. However, there is controversy as to whether B cell clonality also exists in chronic gastritis, hence rendering this approach futile at present.

methodsAn expert panel re-examined the histology and immunohistochemistry of a total of 97 cases of gastric biopsies, including clearcut marginal zone lymphoma, chronic gastritis, and ambiguous cases, applying the Wotherspoon criteria on the basis of haematoxylin-eosin and CD20 immunostainings. In addition, a new and advanced PCR system for detection of clonal IgH gene rearrangements was independently applied in two institutions in each case.

resultsThe overall IgH clonality assessments of both institutions were in total agreement. Overt lymphoma (Wotherspoon score 5) was clonal in 24/26 cases. Chronic gastritis (Wotherspoon scores 1 and 2) was not clonal in 52/53 cases; the clonal case being Wotherspoon score 2. Of 18 cases with ambiguous histology (Wotherspoon scores 3 and 4) four were clonal.

conclusionsUsing advanced PCR technology, clonal gastritis is extremely rare, if it exists at all. Thus B cell clonality in Wotherspoon 3 and 4 cases is regarded as suitable for definitively diagnosing gastric marginal zone lymphoma.

Indexed as

AlgorithmsAntigens, CD20Biomarkers, TumorChronic DiseaseClone CellsDiagnosis, DifferentialGastritisGene Rearrangement, B-Lymphocyte, Heavy ChainGenes, ImmunoglobulinHumansImmunoglobulin Heavy ChainsLymphoma, B-Cell, Marginal ZoneNeoplastic Stem CellsPilot ProjectsPolymerase Chain ReactionReproducibility of ResultsAntigens, CD20Biomarkers, TumorImmunoglobulin Heavy Chains

Identifiers

PMID16423889
PMCPMC1856242
OpenAlexW2131163597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.