ArticleGut2006
Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.
Article in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 72 citations in OpenAlex.
- Review
- Review
- The intestinal epithelial barrier: a therapeutic target?Nature reviews. Gastroenterology & hepatology · 2017Review
- Association between the MYO9B polymorphisms and celiac disease risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- IBD candidate genes and intestinal barrier regulation.Inflammatory bowel diseases · 2014Article
- The myosin superfamily at a glance.Journal of cell science · 2012Review
- Gliadin fragments promote migration of dendritic cells.Journal of cellular and molecular medicine · 2011Article
- MYO9B polymorphisms in multiple sclerosis.European journal of human genetics : EJHG · 2009Article
- Immunopathogenesis of celiac disease.Current gastroenterology reports · 2008Article
- Altered gene expression in highly purified enterocytes from patients with active coeliac disease.BMC genomics · 2008Article
- Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.Clinical and experimental immunology · 2008Review
- IL23R: a susceptibility locus for celiac disease and multiple sclerosis?Genes and immunity · 2008Article
- Genome-wide linkage analysis of 160 North American families with celiac disease.Genes and immunity · 2007Review
- Celiac disease: pathogenesis of a model immunogenetic disease.The Journal of clinical investigation · 2007Review
- A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsDevelopment of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3' region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation.
methodsFour single nucleotide polymorphisms were chosen to tag all common haplotypes of the MYO9B 3' haplotype block (exons 15-27). We genotyped 375 coeliac disease cases and 1366 controls (371 healthy and 995 population based). All individuals were of White UK Caucasian ethnicity.
resultsUK healthy control and population control allele frequencies were similar for all MYO9B variants. Case control analysis showed no significant association of any variant or haplotype with coeliac disease.
conclusionsGenetic variation in MYO9B does not have a major effect on coeliac disease susceptibility in the UK population. Differences between populations, a weaker effect size than originally described, or possibly a type I error in the Dutch study might explain these findings.
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