ArticleThe Journal of physiology2006
Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.
- The Effect of Exercise Training on the Energetic Cost of Cycling.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Effects of exercise followed by a low-carbohydrate diet on peak fat oxidation and mitochondrial coupling control and efficiency in healthy trained men.The Journal of physiology · 2026Trial
- Effects of High-Intensity Interval Training and Continuous Aerobic Training on Health-Fitness, Health Related Quality of Life, and Psychological Measures in College-Aged Smokers.International journal of environmental research and public health · 2022Trial
- The Effect of Different Cadence on Paddling Gross Efficiency and Economy in Stand-Up Paddle Boarding.International journal of environmental research and public health · 2020Trial
- Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.The Journal of physiology · 2017Trial
- Heavy strength training improves running and cycling performance following prolonged submaximal work in well-trained female athletes.Physiological reports · 2017Trial
- Resting and exercise energy metabolism in weight-reduced adults with severe obesity.Obesity (Silver Spring, Md.) · 2016Trial
- Effects of high-intensity interval training on pulmonary function.European journal of applied physiology · 2012Trial
- The slow component of the [Formula: see text] response is associated with the increase in glycolytic contribution.European journal of applied physiology · 2026Article
- Higher legs muscle mass reduces gross mechanical efficiency during moderate intensity cycling in young healthy men.Scientific reports · 2025Article
- Exercise echocardiography for improved assessment of diastolic filling dynamics.Experimental physiology · 2025Article
- Mitochondrial efficiency in resting skeletal muscle in vivo: a novel non-invasive approach using multinuclear magnetic resonance spectroscopy in humans.The Journal of physiology · 2025Article
- Mechanical efficiency: associations with body composition and glycemic profile in healthy adults.European journal of applied physiology · 2024Article
- Leg cycling efficiency is unaltered in healthy aging regardless of sex or training status.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Metabolic features of neutrophilic differentiation of HL-60 cells in hyperglycemic environments.BMJ open diabetes research & care · 2024Article
- Plant-derived compounds normalize platelet bioenergetics and function in hyperglycemia.Research and practice in thrombosis and haemostasis · 2024Article
- Article
- The Acute, Short-, and Long-Term Effects of Endurance Exercise on Skeletal Muscle Transcriptome Profiles.International journal of molecular sciences · 2024Article
- Review
- Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice.Life metabolism · 2023Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the hypothesis that cycling efficiency in vivo is related to mitochondrial efficiency measured in vitro and to investigate the effect of training status on these parameters. Nine endurance trained and nine untrained male subjects (V(O2peak) = 60.4 +/- 1.4 and 37.0 +/- 2.0 ml kg(-1) min(-1), respectively) completed an incremental submaximal efficiency test for determination of cycling efficiency (gross efficiency, work efficiency (WE) and delta efficiency). Muscle biopsies were taken from m. vastus lateralis and analysed for mitochondrial respiration, mitochondrial efficiency (MEff; i.e. P/O ratio), UCP3 protein content and fibre type composition (% MHC I). MEff was determined in isolated mitochondria during maximal (state 3) and submaximal (constant rate of ADP infusion) rates of respiration with pyruvate. The rates of mitochondrial respiration and oxidative phosphorylation per muscle mass were about 40% higher in trained subjects but were not different when expressed per unit citrate synthase (CS) activity (a marker of mitochondrial density). Training status had no influence on WE (trained 28.0 +/- 0.5, untrained 27.7 +/- 0.8%, N.S.). Muscle UCP3 was 52% higher in untrained subjects, when expressed per muscle mass (P < 0.05 versus trained). WE was inversely correlated to UCP3 (r = -0.57, P < 0.05) and positively correlated to percentage MHC I (r = 0.58, P < 0.05). MEff was lower (P < 0.05) at submaximal respiration rates (2.39 +/- 0.01 at 50% V(O2max)) than at state 3 (2.48 +/- 0.01) but was neither influenced by training status nor correlated to cycling efficiency. In conclusion cycling efficiency was not influenced by training status and not correlated to MEff, but was related to type I fibres and inversely related to UCP3. The inverse correlation between WE and UCP3 indicates that extrinsic factors may influence UCP3 activity and thus MEff in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.