ArticleThe Journal of physiology2006
Mechanisms underlying variations in excitation-contraction coupling across the mouse left ventricular free wall.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices.The Journal of general physiology · 2021Article
- Region-specific mechanisms of corticosteroid-mediated inotropy in rat cardiomyocytes.Scientific reports · 2020Article
- SMN-deficiency disrupts SERCA2 expression and intracellular CaSkeletal muscle · 2020Article
- The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models.Frontiers in physiology · 2020Article
- Phase 1 repolarization rate defines CaThe Journal of general physiology · 2019Article
- Transmural Autonomic Regulation of Cardiac Contractility at the Intact Heart Level.Frontiers in physiology · 2019Article
- Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and CaThe Journal of physiology · 2018Article
- Transmural cellular heterogeneity in myocardial electromechanics.The journal of physiological sciences : JPS · 2018Article
- Transmural gradients in ion channel and auxiliary subunit expression.Progress in biophysics and molecular biology · 2016Review
- Transient outward potassium channel: a heart failure mediator.Heart failure reviews · 2015Review
- LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.The Journal of biological chemistry · 2015Article
- Integrating multi-scale data to create a virtual physiological mouse heart.Interface focus · 2013Article
- Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation.American journal of physiology. Heart and circulatory physiology · 2013Article
- Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice.Biophysical journal · 2013Article
- Article
- Analysis of Na(+)/Ca (2+) exchanger (NCX) function and current in murine cardiac myocytes during heart failure.Molecular biology reports · 2012Article
- Regional variation in myofilament length-dependent activation.Pflugers Archiv : European journal of physiology · 2011Review
- The mechanisms underlying ICa heterogeneity across murine left ventricle.Molecular and cellular biochemistry · 2011Article
- How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?Journal of molecular and cellular cardiology · 2010Article
- Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ca(2+) release during excitation-contraction (EC) coupling varies across the left ventricular free wall. Here, we investigated the mechanisms underlying EC coupling differences between mouse left ventricular epicardial (Epi) and endocardial (Endo) myocytes. We found that diastolic and systolic [Ca(2+)](i) was higher in paced Endo than in Epi myocytes. Our data indicated that differences in action potential (AP) waveform between Epi and Endo cells only partially accounted for differences in [Ca(2+)](i). Rather, we found that the amplitude of the [Ca(2+)](i) transient, but not its trigger - the Ca(2+) current - was larger in Endo than in Epi cells. We also found that spontaneous Ca(2+) spark activity was about 2.8-fold higher in Endo than in Epi cells. Interestingly, ryanodine receptor type 2 (RyR2) protein expression was nearly 2-fold higher in Endo than in Epi myocytes. Finally, we observed less Na(+)-Ca(2+) exchanger function in Endo than in Epi cells, which was associated with decreased Ca(2+) efflux during the AP; this contributed to higher diastolic [Ca(2+)](i) and SR Ca(2+) in Endo than in Epi cells during pacing. We propose that transmural differences in AP waveform, SR Ca(2+) release, and Na(+)-Ca(2+) exchanger function underlie differences in [Ca(2+)](i) and EC coupling across the left ventricular free wall.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.