ArticleThe Journal of physiology2006
The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Targeting Anti-Angiogenic VEGFCells · 2022Article
- Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells.World journal of gastroenterology · 2019Article
- Vascular Leaking, a Pivotal and Early Pathogenetic Event in Systemic Sclerosis: Should the Door Be Closed?Frontiers in immunology · 2018Review
- VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease.Circulation research · 2017Article
- Disorders of Vascular Permeability.Annual review of pathology · 2016Review
- Article
- VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.The American journal of pathology · 2013Article
- VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice.American journal of physiology. Renal physiology · 2012Article
- Bevacizumab and intraocular tumors: an intriguing paradox.Molecular vision · 2012Article
- An unexpected tail of VEGF and PlGF in pre-eclampsia.Biochemical Society transactions · 2011Review
- Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines.The FEBS journal · 2011Review
- Downstream exposure to growth factors causes elevated velocity and dilation in arteriolar networks.Journal of vascular research · 2011Article
- VEGF₁₂₁b and VEGF₁₆₅b are weakly angiogenic isoforms of VEGF-A.Molecular cancer · 2010Article
- Murine rVEGF164b, an inhibitory VEGF reduces VEGF-A-dependent endothelial proliferation and barrier dysfunction.Microcirculation (New York, N.Y. : 1994) · 2010Article
- Hypoxia inducible factor-1α (HIF-1α) and some HIF-1 target genes are elevated in experimental glaucoma.Journal of molecular neuroscience : MN · 2010Article
- Overexpression of VEGF165b in podocytes reduces glomerular permeability.Journal of the American Society of Nephrology : JASN · 2010Article
- Vascular endothelial growth factors and vascular permeability.Cardiovascular research · 2010Review
- Investigation of antiangiogenic tumor therapy potential of microencapsulated HEK293 VEGF165b producing cells.Journal of biomedicine & biotechnology · 2010Article
- The anti-angiogenic isoforms of VEGF in health and disease.Biochemical Society transactions · 2009Article
- Therapeutic potential of manipulating VEGF splice isoforms in oncology.Future oncology (London, England) · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vascular endothelial growth factor (VEGF) is the principal agent that increases microvascular permeability during physiological and pathological angiogenesis. VEGF is differentially spliced to form two families of isoforms: VEGF(xxx), and VEGF(xxx)b. Whereas VEGF(165) stimulates angiogenesis, VEGF(165)b is anti-angiogenic. To determine the effect of VEGF(165)b on permeability, hydraulic conductivity (L(p)) was measured in individually perfused microvessels in the mesentery of frogs and rats. As with VEGF(165), VEGF(165)b increased L(p) in amphibian (2.4 +/- 0.3-fold) and mammalian (1.9 +/- 0.2-fold) mesenteric microvessels. A dose-response relationship showed that VEGF(165)b (EC(50), 0.65 pm) was approximately 25 times more potent than VEGF(165) (EC(50), 16 pm) in amphibian microvessels. VEGF(165) has been shown to increase permeability through VEGF receptor 2 (VEGF-R2) signalling. However, VEGF(165)b increased L(p) of frog vessels to the same extent in the presence of the VEGF-R2 inhibitor ZM323881, indicating that it does not increase permeability via VEGF-R2 signalling, and was inhibited by the VEGF receptor inhibitor SU5416 at doses that are specific for VEGF receptor 1 (VEGF-R1). VEGF(165)b, in contrast to VEGF(165), did not result in a sustained chronic increase in L(p). These results show that although VEGF(165)b is anti-angiogenic in the mesentery, it does signal in endothelial cells in vivo resulting in a transient, but not sustained, increase in microvascular L(p), probably through VEGF-R1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.