ArticleThe Journal of biological chemistry2006
Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.
Article in The Journal of biological chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway.International journal of biological sciences · 2020Article
- Activation of Smoothened in the Hedgehog pathway unexpectedly increases GαThe Journal of biological chemistry · 2018Article
- The unfolded protein response selectively targets active smoothened mutants.Molecular and cellular biology · 2013Article
- Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling.Nature communications · 2013Article
- The Hedgehog signal transduction network.Science signaling · 2012Review
- The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.Development (Cambridge, England) · 2012Article
- A quantification of pathway components supports a novel model of Hedgehog signal transduction.The Journal of biological chemistry · 2009Article
- G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.Nature · 2008Article
- Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway.Current biology : CB · 2008Article
- THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.Nature genetics · 2008Article
- A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.Genetics · 2008Article
- Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.Developmental biology · 2007Article
- Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.Genes & development · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The secreted protein Hedgehog (Hh) plays an important role in metazoan development and as a survival factor for many human tumors. In both cases, Hh signaling proceeds through the activation of the seven-transmembrane protein Smoothened (Smo), which is thought to convert the Gli family of transcription factors from transcriptional repressors to transcriptional activators. Here, we provide evidence that Smo signals to the Hh signaling complex, which consists of the kinesin-related protein Costal2 (Cos2), the protein kinase Fused (Fu), and the Drosophila Gli homolog cubitus interruptus (Ci), in two distinct manners. We show that many of the commonly observed molecular events following Hh signaling are not transmitted in a linear fashion but instead are activated through two signals that bifurcate at Smo to independently affect activator and repressor pools of Ci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.