Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Teriparatide vs. calcitonin in the treatment of Asian postmenopausal women with established osteoporosis.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A systematic review on the use of daily subcutaneous administration of teriparatide for treatment of patients with osteoporosis at high risk for fracture in Asia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Pooled it
- Effects of teriparatide in Chinese and Caucasian women with osteoporosis: bridging study on efficacy.Clinical interventions in aging · 2019Trial
- The rhPTH treatment elevates plasma secreted protein acidic and rich in cysteine levels in patients with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Trial
- The effects of intravenous zoledronic acid in Chinese women with postmenopausal osteoporosis.Journal of bone and mineral metabolism · 2011Trial
- The effects of weekly alendronate therapy in Taiwanese males with osteoporosis.Journal of bone and mineral metabolism · 2010Trial
- Effect of teriparatide on bone mineral density and biochemical markers in Japanese women with postmenopausal osteoporosis: a 6-month dose-response study.Journal of bone and mineral metabolism · 2008Trial
- Evaluation of teriparatide as a promoter of mandibular fracture healing: An observational clinical study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Observational
- Clinical evaluation of therapeutic efficacy of Teriparatide in osteoporotic patients with vertebral degeneration.Journal of orthopaedics · 2025Article
- Calcitonin: A useful old friend.Journal of musculoskeletal & neuronal interactions · 2020Review
- Efficacy and Safety of the Biosimilar Recombinant Human Parathyroid Hormone CinnoparIranian journal of public health · 2018Article
- Treatment of post-menopausal osteoporosis: beyond bisphosphonates.Journal of endocrinological investigation · 2015Review
- Back pain in patients with severe osteoporosis on teriparatide or antiresorptives: a prospective observational study in a multiethnic population.Singapore medical journal · 2014Observational
- Vitamin D status in non-supplemented postmenopausal Taiwanese women with osteoporosis and fragility fracture.BMC musculoskeletal disorders · 2014Observational
- Clinical practice guidelines for the prevention and treatment of osteoporosis in Taiwan: summary.Journal of bone and mineral metabolism · 2014Review
- Study on the role of zoledronic acid in treatment of postmenopausal osteoporosis women.Pakistan journal of medical sciences · 2013Article
- Teriparatide: a novel means to ultimately achieve true regeneration!!!Journal of clinical and diagnostic research : JCDR · 2013Article
- Changes in serum runt-related transcription factor 2 levels after a 6-month treatment with recombinant human parathyroid hormone in patients with osteoporosis.Journal of endocrinological investigation · 2012Article
- Is bone quality associated with collagen age?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared the clinical efficacy, safety, and tolerability of daily subcutaneous injections of teriparatide and salmon calcitonin in the treatment of postmenopausal women with established osteoporosis in Taiwan. This 6-month, multicenter, randomized, controlled study enrolled 63 women with established osteoporosis. They were randomized to receive either teriparatide 20 microg or calcitonin 100 IU daily in an open-label fashion. Lumber spine, femoral neck, total hip bone mineral density (BMD), and biochemical markers of bone turnover were measured, and adverse events and tolerability were recorded. The results at 6 months showed that patients using teriparatide had larger mean increases in spinal BMD than those who used calcitonin (4.5% vs. 0.1%), but the BMD changes in these two groups at the femoral neck and the total hip were not significant. There were also larger mean increases in bone markers in the teriparatide group than in the calcitonin group (bone specific alkaline phosphatase 142% vs. 37%; osteocalcin 154% vs. 23%). We conclude that teriparatide has more positive effects on bone formation than salmon calcitonin, as shown by the larger increments of lumbar spine BMD and bone formation markers, and caused only mild adverse events and no significant change in liver, kidney or hematological parameters. Compared with the published global results, teriparatide seems to be equally effective and safe to use in this Asian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.