ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
A signaling mechanism from G alpha q-protein-coupled metabotropic glutamate receptors to gene expression: role of the c-Jun N-terminal kinase pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- The involvement of the mGluR5-mediated JNK signaling pathway in rats with diabetic retinopathy.International ophthalmology · 2019Article
- Role of DNA Methylation in Hypobaric Hypoxia-Induced Neurodegeneration and Spatial Memory Impairment.Annals of neurosciences · 2018Article
- Metabotropic Glutamate Receptors in Glial Cells: A New Potential Target for Neuroprotection?Frontiers in molecular neuroscience · 2018Review
- GaCellular and molecular life sciences : CMLS · 2017Review
- Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole.PloS one · 2017Article
- Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors.Journal of neuroscience research · 2015Article
- c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins.Journal of neurochemistry · 2013Article
- The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration.Neuroscience · 2013Article
- Amphetamine increases phosphorylation of MAPK/ERK at synaptic sites in the rat striatum and medial prefrontal cortex.Brain research · 2013Article
- Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Molecular pharmacology · 2012Article
- Cocaine facilitates PKC maturation by upregulating its phosphorylation at the activation loop in rat striatal neurons in vivo.Brain research · 2012Article
- Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases.Frontiers in pharmacology · 2012Article
- Cocaine increases phosphorylation of MeCP2 in the rat striatum in vivo: a differential role of NMDA receptors.Neurochemistry international · 2011Article
- Linking cocaine to endoplasmic reticulum in striatal neurons: role of glutamate receptors.Basal ganglia · 2011Article
- Effects of mutant huntingtin on mGluR5-mediated dual signaling pathways: implications for therapeutic interventions.Cellular and molecular neurobiology · 2010Article
- Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo.Brain research · 2010Article
- Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms.Pharmacological reviews · 2009Review
- Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo.European journal of pharmacology · 2009Article
- Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.Psychopharmacology · 2009Article
- Regulation of extracellular signal-regulated kinase phosphorylation in cultured rat striatal neurons.Brain research bulletin · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Galphaq-protein-coupled group I metabotropic glutamate receptors (mGluRs) are densely expressed in brain neurons and are actively involved in various cellular activities. In this study, we investigated the role of group I mGluRs in regulating the c-Jun N-terminal kinase (JNK)/stress-activated protein kinase in cultured neurons. We found that selective activation of mGluR5 induced a rapid and transient phosphorylation of JNK. In a series of studies to determine the mechanisms, we found that the conventional mGluR5-associated signaling pathways (inositol-1,4,5-triphosphate-mediated Ca2+ release and activation of protein kinase C) were not involved in the mGluR5 regulation. Instead, ligand stimulation of mGluR5 caused a dynamic transactivation of the epidermal growth factor (EGF) receptor, which in turn triggered a downstream signaling pathway to upregulate JNK phosphorylation. Furthermore, the mGluR5-dependent JNK activation specifically activated c-Jun, but not activating transcription factor-2 or JunD, and increased activator protein-1 (AP-1)-mediated endogenous transcriptional activity. Together, we identified a novel mGluR5-to-nucleus communication through the EGF/JNK pathway, which functions to regulate AP-1-mediated transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.