ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction of exuberant retinal axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Interactions between Guidance Cues and Neuronal Activity: Therapeutic Insights from Mouse Models.International journal of molecular sciences · 2023Review
- Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains.JCI insight · 2022Article
- Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Retinal Axon Interplay for Binocular Mapping.Frontiers in neural circuits · 2021Article
- Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Molecular guidance cues in the development of visual pathway.Protein & cell · 2018Review
- RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.Scientific reports · 2017Article
- Activity-Dependent Synaptic Refinement: New Insights fromFrontiers in systems neuroscience · 2017Review
- Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.Developmental neurobiology · 2017Article
- A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors.Nature communications · 2016Article
- Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.Neuropharmacology · 2015Article
- Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.Neuroscience · 2015Article
- Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.Frontiers in cellular neuroscience · 2014Review
- Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization.PloS one · 2013Article
- Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Role of adenylate cyclase 1 in retinofugal map development.The Journal of comparative neurology · 2012Article
- Termination and initial branch formation of SNAP-25-deficient thalamocortical fibres in heterochronic organotypic co-cultures.The European journal of neuroscience · 2012Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The calcium-stimulated adenylate cyclase 1 (AC1) has been shown to be required for the refinement of the retinotopic map, but the mechanisms involved are not known. To investigate this question, we devised a retinotectal coculture preparation that reproduces the gradual acquisition of topographic specificity along the rostrocaudal axis of the superior colliculus (SC). Temporal retinal axons invade the entire SC at 4 d in vitro (DIV) and eliminate exuberant branches caudally by 12 DIV. Temporal and nasal axons form branches preferentially in the rostral or caudal SC, respectively. Retinal explants from AC1-deficient mice, AC1(brl/brl), maintain exuberant branches and lose the regional selectivity of branching when confronted with wild-type (WT) SC. Conversely, WT retinas correctly target AC1(brl/brl) collicular explants. The effects of AC1 loss of function in the retina are mimicked by the blockade of ephrin-A5 signaling in WT cocultures. Video microscopic analyses show that AC1(brl/brl) axons have modified responses to ephrin-A5: the collapse of the growth cones occurs, but the rearward movement of the axon is arrested. Our results demonstrate a presynaptic, cell autonomous role of AC1 in the retina and further indicate that AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during the refinement of the retinotopic map.
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