Evidence map›Paper›PMID 16420673›Full record

ArticleGenome biology2005

Discovery of biological networks from diverse functional genomic data.

Chad L Myers, Drew Robson, Adam Wible, Matthew A Hibbs, Camelia Chiriac, Chandra L Theesfeld, Kara Dolinski, Olga G Troyanskaya

Abstract read
In one paragraph

Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. GeneMANIA update 2018.Nucleic acids research · 2018
    Article
  11. Article
  12. Article
  13. A graph theoretical approach to data fusion.Statistical applications in genetics and molecular biology · 2016
    Article
  14. Review
  15. Implications of Big Data for cell biology.Molecular biology of the cell · 2015
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chad L MyersDepartment of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08544, USA. clmyers@princeton.edu
Drew Robson
Adam Wible
Matthew A Hibbs
Camelia Chiriac
Chandra L Theesfeld
Kara Dolinski
Olga G Troyanskaya

Funding

Spatial Patterning During DevelopmentP50GM071508 · NIGMS · PRINCETON UNIVERSITY · PI POWELL, SUSAN M · 2004 to 2013
$30.6M
Quantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9M
lntegration and Visualization of Diverse Biological DataR01GM071966 · NIGMS · PRINCETON UNIVERSITY · PI TROYANSKAYA, OLGA G · 2005 to 2022
$6.4M
Integrating and Disseminating Functional Genomics DataR01HG003471 · NHGRI · PRINCETON UNIVERSITY · PI BOTSTEIN, DAVID · 2005 to 2007
$1.7M
NHGRI NIH HHS R01 HG003471NHGRI NIH HHS T32 HG003284NIGMS NIH HHS P50 GM071508NIGMS NIH HHS R01 GM071966
6 · The paper itself

Abstract

We have developed a general probabilistic system for query-based discovery of pathway-specific networks through integration of diverse genome-wide data. This framework was validated by accurately recovering known networks for 31 biological processes in Saccharomyces cerevisiae and experimentally verifying predictions for the process of chromosomal segregation. Our system, bioPIXIE, a public, comprehensive system for integration, analysis, and visualization of biological network predictions for S. cerevisiae, is freely accessible over the worldwide web.

Indexed as

GenomicsBayes TheoremCell Cycle ProteinsComputational BiologyComputer GraphicsHSP90 Heat-Shock ProteinsMolecular ChaperonesProtein Interaction MappingReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCDC37 protein, S cerevisiaeCell Cycle ProteinsHSP90 Heat-Shock ProteinsMolecular ChaperonesSaccharomyces cerevisiae Proteins

Identifiers

PMID16420673
PMCPMC1414113

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.