ArticleJournal of anatomy2006
Calcium phosphate microcrystal deposition in the human intervertebral disc.
Article in Journal of anatomy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 55 citations in OpenAlex.
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Usefulness of Detecting Brain-Derived Neurotrophic Factor in Intervertebral Disc Degeneration of the Lumbosacral Spine.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Changes in Elements and Relationships among Elements in Intervertebral Disc Degeneration.International journal of environmental research and public health · 2022Article
- Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review.Rheumatology international · 2022Review
- Calcium pyrophosphate dihydrate crystal deposition disease and retro-odontoid pseudotumor rupture managed via posterior occipital cervical instrumented fusion: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Severe calcium pyrophosphate dihydrate deposition disease of the metacarpophalangeal joints.BMJ case reports · 2018Article
- Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation.Tissue engineering and regenerative medicine · 2017Article
- Calcium Pyrophosphate Deposition Disease.The New England journal of medicine · 2016Review
- Inflammation in intervertebral disc degeneration and regeneration.Journal of the Royal Society, Interface · 2015Review
- Retro-odontoid calcium pyrophosphate dehydrate deposition: surgical management and review of the literature.Evidence-based spine-care journal · 2014Article
- Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2009Article
- Characterization of articular calcium-containing crystals by synchrotron FTIR.Osteoarthritis and cartilage · 2008Article
- Detection of calcium phosphate crystals in the joint fluid of patients with osteoarthritis - analytical approaches and challenges.The Analyst · 2008Review
- Calcium orthophosphates (CaPOProgress in biomaterialsArticle
- Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of crystals have been identified in both normal and pathological connective tissues. Calcium phosphate 'cuboidal' microcrystal deposition has been found, using transmission electron microscopy (TEM), in femoral articular cartilage, where they are distributed as a band 5-50 microm beneath the articular surface. These cuboid microcrystals have been identified as magnesium whitlockite. Our objective was to investigate their presence in the human intervertebral disc. In this study, two degenerate and 15 scoliotic discs were examined using light microscopy and TEM techniques to determine the presence of calcium phosphate crystals. Calcium pyrophosphate dihydrate (CPPD) deposition was identified in one degenerate disc specimen. Using TEM and electron probe analysis, cuboid microcrystals were identified in the annulus fibrosus and nucleus pulposus of both degenerate specimens, but not in the discs from young scoliotic patients. Cuboid microcrystal deposition was found predominantly around cells, which were mainly necrotic, with some association with extracellular lipidic/membranous debris. This is the first TEM report of whitlockite in the intervertebral disc. In one specimen coexistence of cuboid and CPPD crystal deposition was found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.