ArticleWorld journal of gastroenterology2005
Distinct immune response induced by peptidoglycan derived from Lactobacillus sp.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 62 citations in OpenAlex.
- Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application.Frontiers in microbiology · 2026Review
- Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.Biomolecules · 2025Review
- Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity.Scientific reports · 2025Article
- The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management.Oral health & preventive dentistry · 2024Review
- Peptidoglycan derived fromInnate immunity · 2020Article
- Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.Cancer drug resistance (Alhambra, Calif.) · 2020Article
- A Novel Phage PD-6A3, and Its Endolysin Ply6A3, With Extended Lytic Activity AgainstFrontiers in microbiology · 2018Article
- Anti-tumour immune effect of oral administration of Lactobacillus plantarum to CT26 tumour-bearing mice.Journal of biosciences · 2015Article
- Recent molecular insights into rickettsial pathogenesis and immunity.Future microbiology · 2013Review
- Intestinal microbiota, probiotics and human gastrointestinal cancers.Journal of gastrointestinal cancer · 2013Review
- MyD88 associated ROS generation is crucial for Lactobacillus induced IL-12 production in macrophage.PloS one · 2012Article
- Murine mammary carcinoma cells and CD11c(+) dendritic cells elicit distinct responses to lipopolysaccharide and exhibit differential expression of genes required for TLR4 signaling.Cellular immunology · 2010Article
- Gastrointestinal microflora, food components and colon cancer prevention.The Journal of nutritional biochemistry · 2009Review
- Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer.World journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo analyze the distinct immune responses induced by Lactobacillus peptidoglycan (PG).
methodsBALB/c mice were intraperitoneally injected with PG once a day for three consecutive days. Peritoneal macrophage and splenocyte mRNA was extracted and the gene expression profile was studied using high-density oligonucleotide microarrays. Inhibitory effects of Lactobacillus PG on colon tumor tissue were studied in vitro and in vivo.
resultsThe gene expression profiles revealed that the TLR-NF-kappaB; and Jak-STAT signaling pathways were highly activated. An inflammatory phenotype was induced when peritoneal macrophages were initially exposed to Lactobacillus PG and switched to a more complex phenotype when BALB/c mice were treated with three doses of Lactobacillus PG. A protective physiological inflammatory response was induced after three consecutive days of PG treatment. It was tending toward Th1 dominant immune response. Lactobacillus PG also appeared to induce a significant in vivo anti-colon tumor effect.
conclusionLactobacillus PG is responsible for certain immune responses induced by Lactobacilli. Anti-tumor effects of Lactobacilli are likely to attribute to the activation of macrophages by PG expressed on the bacterial cell surface.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.