ArticleWorld journal of gastroenterology2005
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Metabolism and Targeted Therapy of Fibrosis in Chronic Pancreatitis: A Review.International journal of medical sciences · 2025Review
- Closest horizons of Hsp70 engagement to manage neurodegeneration.Frontiers in molecular neuroscience · 2023Review
- Capsaicin-Sensitive Sensory Nerves Are Necessary for the Protective Effect of Ghrelin in Cerulein-Induced Acute Pancreatitis in Rats.International journal of molecular sciences · 2017Article
- PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Pathogenesis of pancreatic cancer: lessons from animal models.Toxicologic pathology · 2014Review
- N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis.Gut and liver · 2013Article
- Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice.PloS one · 2012Article
- Activated and inactivated PPARs-γ modulate experimentally induced colitis in rats.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Pioglitazone: a promising therapeutic tool in sodium taurocholate-induced severe acute pancreatitis.Digestive diseases and sciences · 2011Article
- The selective inhibition of type IV phosphodiesterase attenuates the severity of the acute pancreatitis in rats.Digestive diseases and sciences · 2009Article
- Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma.Critical care medicine · 2009Article
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Authors and funding
9 authors.
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Abstract
aimTo determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-gamma (PPARgamma) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas.
methodsAP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1beta (IL-1beta) and IL-10 were determined. Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1beta and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein.
resultsPioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1beta and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment.
conclusionPioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1beta and to the overexpression of HSP70. PPARgamma ligands could represent a new therapeutic option in the treatment of AP.
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