ArticleThe Journal of cell biology2006
Structural transitions in the synaptic SNARE complex during Ca2+-triggered exocytosis.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Fusion Pores as Regulators of Quantal Size and Cellular Physiology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Synaptophysin transmembrane domain III controls fusion pore dynamics in CaBiophysical journal · 2023Article
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- Stability profile of the neuronal SNARE complex reflects its potency to drive fast membrane fusion.Biophysical journal · 2022Article
- Cholesterol stabilizes recombinant exocytic fusion pores by altering membrane bending rigidity.Biophysical journal · 2021Article
- Synaptic dendritic activity modulates the single synaptic event.Cognitive neurodynamics · 2021Article
- The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review.Neuronal signaling · 2017Review
- The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores.The Journal of biological chemistry · 2016Article
- Article
- All three components of the neuronal SNARE complex contribute to secretory vesicle docking.The Journal of cell biology · 2012Article
- The SNARE complex in neuronal and sensory cells.Molecular and cellular neurosciences · 2012Review
- Improved probes for hybrid voltage sensor imaging.Biophysical journal · 2010Article
- SNARE complex zipping as a driving force in the dilation of proteinaceous fusion pores.The Journal of membrane biology · 2010Article
- Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis.The Journal of cell biology · 2010Article
- Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.Molecular biology of the cell · 2009Article
- Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval.Trends in neurosciences · 2008Review
- Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism.The Journal of physiology · 2008Article
- The fusion pores of Ca2+ -triggered exocytosis.Nature structural & molecular biology · 2008Review
- Interactions between neuronal fusion proteins explored by molecular dynamics.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The synaptic SNARE complex is a highly stable four-helix bundle that links the vesicle and plasma membranes and plays an essential role in the Ca(2+)-triggered release of neurotransmitters and hormones. An understanding has yet to be achieved of how this complex assembles and undergoes structural transitions during exocytosis. To investigate this question, we have mutated residues within the hydrophobic core of the SNARE complex along the entire length of all four chains and examined the consequences using amperometry to measure fusion pore opening and dilation. Mutations throughout the SNARE complex reduced two distinct rate processes before fusion pore opening to different degrees. These results suggest that two distinct, fully assembled conformations of the SNARE complex drive transitions leading to open fusion pores. In contrast, a smaller number of mutations that were scattered through the SNARE complex but were somewhat concentrated in the membrane-distal half stabilized open fusion pores. These results suggest that a structural transition within a partially disassembled complex drives the dilation of open fusion pores. The dependence of these three rate processes on position within the SNARE complex does not support vectorial SNARE complex zipping during exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.