ArticleThe Journal of general physiology2006
Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Functional Potassium Channels in Macrophages.The Journal of membrane biology · 2023Review
- KCells · 2020Review
- New saliva secretion model based on the expression of NaPflugers Archiv : European journal of physiology · 2018Article
- Neuronal expression of the intermediate conductance calcium-activated potassium channel KCa3.1 in the mammalian central nervous system.Pflugers Archiv : European journal of physiology · 2015Article
- Ca²⁺-dependent K⁺ channels in exocrine salivary glands.Cell calcium · 2014Review
- Laminar shear stress upregulates endothelial Ca²⁺-activated K⁺ channels KCa2.3 and KCa3.1 via a Ca²⁺/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.American journal of physiology. Heart and circulatory physiology · 2013Article
- Modelling the effects of calcium waves and oscillations on saliva secretion.Journal of theoretical biology · 2012Article
- Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.Human genetics · 2012Article
- Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels.Gastroenterology · 2012Article
- Apical Ca2+-activated potassium channels in mouse parotid acinar cells.The Journal of general physiology · 2012Article
- The LRRC26 protein selectively alters the efficacy of BK channel activators.Molecular pharmacology · 2012Article
- Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- A dynamic model of saliva secretion.Journal of theoretical biology · 2010Article
- The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels.American journal of physiology. Cell physiology · 2009Article
- A mathematical model of fluid secretion from a parotid acinar cell.Journal of theoretical biology · 2007Article
- Abolition of Ca2+-mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+-dependent K+ channel Kcnn4.The Journal of physiology · 2007Article
- Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands.The Journal of physiology · 2007Article
- Mechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel.Channels (Austin, Tex.)Article
- Ca2+-activated K channels in parotid acinar cells: The functional basis for the hyperpolarized activation of BK channels.Channels (Austin, Tex.)Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The complexity of mammalian physiology requires a diverse array of ion channel proteins. This diversity extends even to a single family of channels. For example, the family of Ca2+-activated K channels contains three structural subfamilies characterized by small, intermediate, and large single channel conductances. Many cells and tissues, including neurons, vascular smooth muscle, endothelial cells, macrophages, and salivary glands express more than a single class of these channels, raising questions about their specific physiological roles. We demonstrate here a novel interaction between two types of Ca2+-activated K channels: maxi-K channels, encoded by the KCa1.1 gene, and IK1 channels (KCa3.1). In both native parotid acinar cells and in a heterologous expression system, activation of IK1 channels inhibits maxi-K activity. This interaction was independent of the mode of activation of the IK1 channels: direct application of Ca2+, muscarinic receptor stimulation, or by direct chemical activation of the IK1 channels. The IK1-induced inhibition of maxi-K activity occurred in small, cell-free membrane patches and was due to a reduction in the maxi-K channel open probability and not to a change in the single channel current level. These data suggest that IK1 channels inhibit maxi-K channel activity via a direct, membrane-delimited interaction between the channel proteins. A quantitative analysis indicates that each maxi-K channel may be surrounded by four IK1 channels and will be inhibited if any one of these IK1 channels opens. This novel, regulated inhibition of maxi-K channels by activation of IK1 adds to the complexity of the properties of these Ca2+-activated K channels and likely contributes to the diversity of their functional roles.
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