ArticleThe Journal of experimental medicine2006
Stoichiometry of the murine gammadelta T cell receptor.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering.Cell reports · 2024Article
- Modulating T Cell Responses by Targeting CD3.Cancers · 2023Review
- Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy.Frontiers in immunology · 2021Review
- From thymus to periphery: Molecular basis of effector γδ-T cell differentiation.Immunological reviews · 2020Review
- Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity.Immune network · 2020Review
- T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020Review
- T cell receptor signaling for γδT cell development.Inflammation and regeneration · 2019Review
- TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.Nature immunology · 2016Article
- Structure of the chicken CD3εδ/γ heterodimer and its assembly with the αβT cell receptor.The Journal of biological chemistry · 2014Article
- Stoichiometry of HLA class II-invariant chain oligomers.PloS one · 2011Article
- Decision checkpoints in the thymus.Nature immunology · 2010Review
- ITAM-mediated signaling by the T-cell antigen receptor.Cold Spring Harbor perspectives in biology · 2010Review
- Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Cold Spring Harbor perspectives in biology · 2010Review
- Evidence for a functional sidedness to the alphabetaTCR.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The T cell receptor for antigen (TCR) complex is organized into two functional domains: the antigen-binding clonotypic heterodimer and the signal-transducing invariant CD3 and TCRzeta chains. In most vertebrates, there are two different clonotypic heterodimers (TCRalphabeta and TCRgammadelta) that define the alphabeta and gammadelta T cell lineages, respectively. alphabeta- and gammadeltaTCRs also differ in their invariant chain subunit composition, in that alphabetaTCRs contain CD3gammaepsilon and CD3deltaepsilon dimers, whereas gammadeltaTCRs contain only CD3gammaepsilon dimers. This difference in subunit composition of the alphabeta- and gammadeltaTCRs raises the question of whether the stoichiometries of these receptor complexes are different. As the stoichiometry of the murine gammadeltaTCR has not been previously investigated, we used two quantitative immunofluorescent approaches to determine the valency of TCRgammadelta heterodimers and CD3gammaepsilon dimers in surface murine gammadeltaTCR complexes. Our results support a model of murine gammadeltaTCR stoichiometry in which there are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer.
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Registered trials
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