ArticleProceedings of the National Academy of Sciences of the United States of America2006
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Modulation of Pancreatic Activity by Ghrelin and Its Potential Effects on Acute Pancreatitis.Digestive diseases and sciences · 2026Review
- Article
- Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.Immunity · 2020Article
- The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease.Frontiers in neuroscience · 2020Review
- Genetic architecture of human plasma lipidome and its link to cardiovascular disease.Nature communications · 2019Article
- Ghrelin regulation of glucose metabolism.Journal of neuroendocrinology · 2019Review
- Ghrelin-ghrelin O-acyltransferase system in the pathogenesis of nonalcoholic fatty liver disease.World journal of gastroenterology · 2015Review
- Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets.PLoS genetics · 2014Article
- Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance.World journal of diabetes · 2014Review
- Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Structure and physiological actions of ghrelin.Scientifica · 2013Review
- Ghrelin's second life: from appetite stimulator to glucose regulator.World journal of gastroenterology · 2012Review
- Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons.The Journal of biological chemistry · 2012Article
- Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.The Journal of biological chemistry · 2010Article
- Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells.BMC cancer · 2010Article
- The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.The Journal of biological chemistry · 2010Article
- Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications.International journal of peptides · 2010Article
- Exogenous ghrelin enhances endocrine and exocrine regeneration in pancreatectomized rats.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.Diabetes · 2009Article
- Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.American journal of physiology. Renal physiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ghrelin is a newly discovered peptide and an endogenous ligand for growth hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various central and peripheral effects, including GH secretion, food intake, and gastric and cardiac effects. Ghrelin and the GHS receptor are expressed also in pancreatic islets. We have identified several ghrelin-induced genes by PCR-select subtraction methods, among which is a beta-cell autoantigen for type 1 diabetes, IA-2beta. Administration of ghrelin increased IA-2beta mRNA in mouse brain, pancreas, and insulinoma cell lines (MIN6 and betaTC3). However, the expression of IA-2, another structurally related beta-cell autoantigen, was not induced by ghrelin. Administration of ghrelin or overexpression of IA-2beta, but not overexpression of IA-2, inhibited glucose-stimulated insulin secretion in MIN6 insulinoma cells and, moreover, inhibition of IA-2beta expression by the RNA interference technique ameliorated ghrelin's inhibitory effects on glucose-stimulated insulin secretion. These findings strongly suggest that inhibitory effects of ghrelin on glucose-stimulated insulin secretion are at least partly due to increased expression of IA-2beta induced by ghrelin. Our data demonstrate the link among ghrelin, IA-2beta, and glucose-stimulated insulin secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.