ArticleProceedings of the National Academy of Sciences of the United States of America2006
Reproductive protein protects functionally sterile honey bee workers from oxidative stress.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers.
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Who cites it
241 citing papers in PubMed, 582 citations in OpenAlex.
- Disruption of Antioxidant Defense Systems in Honey Bees and Wild Bees Under Environmental Xenobiotic Pressure.Antioxidants (Basel, Switzerland) · 2026Review
- Oocyte Aging as a Systems-Level Failure of Cellular Quality Control Networks: Insights from Comparative Biology.Biology · 2026Review
- Honey bee nutritranscriptomics reveals key insights towards precision nutrition.Journal of advanced research · 2026Article
- Population Genetic Study ofEcology and evolution · 2026Article
- Review
- Susceptibility to the Neonicotinoid Pesticide Imidacloprid Is Linked to Life History Regulation in Honey Bees (Apis mellifera L.).Molecular ecology · 2026Article
- Honeybee aging as an emergent property of a self-organizing dissipative system.Frontiers in systems biology · 2026Article
- Innate defense mechanisms against Nosema ceranae in hygienic honey bee (Apis mellifera) colonies.PloS one · 2026Article
- Integrating WGCNA, TCN, and Alternative Splicing to Map Early Caste Programs in Day-2 Honeybee Larvae.Genes · 2025Article
- Age, caste, and social context shape ovarian morphology and transcriptomic profiles in red harvester ants.npj aging · 2025Article
- Behavioral and molecular disruptions in honey bees induced by lithium chloride exposure.Scientific reports · 2025Article
- Vitellogenin plays a role in regulating honey bee swarming.Scientific reports · 2025Article
- AI-enhanced marker-assisted selection concept for the multifunctional honey bee (Hymenoptera: Apidea) protein Vitellogenin (Vg).Journal of economic entomology · 2025Article
- Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025Article
- Neuronal Plasticity in the Mushroom Bodies of Winter Bees Is Retained Despite Substantially Advanced Age.Developmental neurobiology · 2025Article
- Low-concentration lead stress enhanced the reproductive potential of Aleuroglyphus ovatus (Troupeau) (Acarina: Acaridae) by upregulating both the expression level and protein level of Vitellogenin gene.Experimental & applied acarology · 2025Article
- Antioxidant Potential of Pollen Polyphenols in Mitigating Environmental Stress in Honeybees (Antioxidants (Basel, Switzerland) · 2025Review
- The antioxidant system was unexpectedly strongly suppressed in apis mellifera worker bees emerged from larvae reared on combs adulterated with paraffin or stearin.Scientific reports · 2025Article
- Functional Elucidation ofInsects · 2025Article
- Hypoxia extends lifespan but does not alter telomere length or oxidative stress in a solitary bee (Megachile rotundata).The Journal of experimental biology · 2025Article
181 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Research on aging shows that regulatory pathways of fertility and senescence are closely interlinked. However, evolutionary theories on social species propose that lifelong care for offspring can shape the course of senescence beyond the restricted context of reproductive capability. These observations suggest that control circuits of aging are remodeled in social organisms with continuing care for offspring. Here, we studied a circuit of aging in the honey bee (Apis mellifera). The bee is characterized by the presence of a long-lived reproductive queen caste and a shorter-lived caste of female workers that are life-long alloparental care givers. We focus on the role of the conserved yolk precursor gene vitellogenin that, in Caenorhabditis elegans, shortens lifespan as a downstream element of the insulin/insulin-like growth factor signaling cascade. Vitellogenin protein is synthesized at high levels in honey bee queens and is abundant in long-lived workers. We establish that vitellogenin gene activity protects worker bees from oxidative stress. Our finding suggests that one mechanistic explanation for patterns of longevity in bees is that a reproductive regulatory pathway has been remodeled to extend life. This perspective is of considerable relevance to research on longevity regulation that builds largely on inference from solitary model species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.