ArticleProceedings of the National Academy of Sciences of the United States of America2006
Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Pooled it
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- Identification of enhancer of mRNA decapping 4 as a novel fusion partner ofBlood advances · 2019Article
- Not Only Mutations Matter: Molecular Picture of Acute Myeloid Leukemia Emerging from Transcriptome Studies.Journal of oncology · 2019Review
- Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019Review
- Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.Molecules and cells · 2018Article
- Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation.Protein science : a publication of the Protein Society · 2017Article
- SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis.BMC neurology · 2014Article
- A comprehensive look at transcription factor gene expression changes in colorectal adenomas.BMC cancer · 2014Article
- Analysis of Chromosomal Aberrations and FLT3 gene Mutations in Childhood Acute Myelogenous Leukemia Patients.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2012Article
- Article
- Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia.Cell cycle (Georgetown, Tex.) · 2011Review
- Article
- Application of serial analysis of gene expression to the study of human genetic disease.Human genetics · 2009Review
- High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.The Journal of clinical investigation · 2009Article
- Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B experience.International journal of oncology · 2008Article
- The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation.Leukemia · 2007Article
- Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model.BMC bioinformatics · 2007Article
- Review
Corrections and comments
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Authors and funding
23 authors at 1 institution in 1 country.
Funding
Abstract
Identification of the specific cytogenetic abnormality is one of the critical steps for classification of acute myeloblastic leukemia (AML) which influences the selection of appropriate therapy and provides information about disease prognosis. However at present, the genetic complexity of AML is only partially understood. To obtain a comprehensive, unbiased, quantitative measure, we performed serial analysis of gene expression (SAGE) on CD15(+) myeloid progenitor cells from 22 AML patients who had four of the most common translocations, namely t(8;21), t(15;17), t(9;11), and inv(16). The quantitative data provide clear evidence that the major change in all these translocation-carrying leukemias is a decrease in expression of the majority of transcripts compared with normal CD15(+) cells. From a total of 1,247,535 SAGE tags, we identified 2,604 transcripts whose expression was significantly altered in these leukemias compared with normal myeloid progenitor cells. The gene ontology of the 1,110 transcripts that matched known genes revealed that each translocation had a uniquely altered profile in various functional categories including regulation of transcription, cell cycle, protein synthesis, and apoptosis. Our global analysis of gene expression of common translocations in AML can focus attention on the function of the genes with altered expression for future biological studies as well as highlight genes/pathways for more specifically targeted therapy.
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