ArticleThe Biochemical journal2006
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Unveiling the Mechanism of Retinoic Acid Therapy for Cutaneous Warts: Insights from Multi-Omics Integration.Clinical, cosmetic and investigational dermatology · 2024Article
- Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization.Epigenetics & chromatin · 2023Article
- Insights into vitamin A in bladder cancer, lack of attention to gut microbiota?Frontiers in immunology · 2023Review
- Review
- Short-Chain Fatty Acids Calibrate RARα Activity Regulating Food Sensitization.Frontiers in immunology · 2021Article
- Nuclear receptor phosphorylation in xenobiotic signal transduction.The Journal of biological chemistry · 2020Review
- Bacterial Quorum Sensing Molecules Promote Allergic Airway Inflammation by Activating the Retinoic Acid Response.iScience · 2020Article
- Hybrid analysis of gene dynamics predicts context-specific expression and offers regulatory insights.Bioinformatics (Oxford, England) · 2019Article
- The potential of retinoids for combination therapy of lung cancer: Updates and future directions.Pharmacological research · 2019Review
- Calreticulin regulates MYCN expression to control neuronal differentiation and stemness of neuroblastoma.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Retinoic acid receptor α facilitates human colorectal cancer progression via Akt and MMP2 signaling.OncoTargets and therapy · 2019Article
- An oncogenic function of retinoic acid receptor-α in the development of laryngeal squamous cell carcinoma.Oncology letters · 2017Article
- NLS‑RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway.Molecular medicine reports · 2016Article
- Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen.Scientific reports · 2016Article
- Nuclear receptors and the Warburg effect in cancer.International journal of cancer · 2015Review
- An ATRActive future for differentiation therapy in AML.Blood reviews · 2015Article
- Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling.Journal of clinical medicine · 2014Review
- Vitamin A and retinoid signaling: genomic and nongenomic effects.Journal of lipid research · 2013Review
- Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.Molecular cancer · 2013Article
- Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA.Oncogene · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARalpha (retinoic acid receptor alpha) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of NSCLC cells (non-small cell lung cancer cells), but the aetiology of this resistance in the remainder has not been fully elucidated [Srinivas, Juroske, Kalyankrishna, Cody, Price, Xu, Narayanan, Weigel and Kurie (2005) Mol. Cell. Biol. 25, 1054-1069]. In the present study, we report that Akt, which is constitutively activated in NSCLC cells, phosphorylates RARalpha and inhibits its transactivation. Biochemical and functional analyses showed that Akt interacts with RARalpha and phosphorylates the Ser96 residue of its DNA-binding domain. Mutation of Ser96 to alanine abrogated the suppressive effect of Akt. Overexpression of a dominant-negative form of Akt in an NSCLC cell line decreased RAR phosphorylation, increased RAR transactivation and enhanced the growth-inhibitory effects of an RAR ligand. The findings presented here show that Akt inhibits RAR transactivation and contributes to retinoid resistance in a subset of NSCLC cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.