ReviewBiochemical Society transactions2006
Clathrin and synaptic vesicle endocytosis: studies at the squid giant synapse.
Review in Biochemical Society transactions, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- DNAJC6 Parkinson's disease: Endolysosomal dysfunction and emerging roles for oligodendrocytes.NPJ Parkinson's disease · 2026Review
- α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes.The Journal of biological chemistry · 2025Article
- Neuronal functions of adaptor complexes involved in protein sorting.Current opinion in neurobiology · 2018Review
- Acute Manipulations of Clathrin-Mediated Endocytosis at Presynaptic Nerve Terminals.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Sensing Exocytosis and Triggering Endocytosis at Synapses: Synaptic Vesicle Exocytosis-Endocytosis Coupling.Frontiers in cellular neuroscience · 2018Review
- Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling.Frontiers in cellular neuroscience · 2018Review
- Clathrin-Dependent Uptake of Paraquat into SH-SY5Y Cells and Its Internalization into Different Subcellular Compartments.Neurotoxicity research · 2017Article
- The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion.Nature communications · 2016Article
- Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain.Biochemistry · 2015Article
- Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones.Frontiers in molecular biosciences · 2015Review
- Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline.Frontiers in synaptic neuroscience · 2014Article
- Presynaptic membrane retrieval and endosome biology: defining molecularly heterogeneous synaptic vesicles.Cold Spring Harbor perspectives in biology · 2013Review
- Clathrin-coated vesicles from brain have small payloads: a cryo-electron tomographic study.Journal of structural biology · 2013Article
- A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A neurotoxic phospholipase A2 impairs yeast amphiphysin activity and reduces endocytosis.PloS one · 2012Article
- Synaptic vesicle recycling at CNS snapses without AP-2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans.The Journal of cell biology · 2008Article
- Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis.Molecular biology of the cell · 2008Article
- Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- 'Fractional recovery' analysis of a presynaptic synaptotagmin 1-anchored endocytic protein complex.PloS one · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The role of clathrin-mediated endocytosis in SV (synaptic vesicle) recycling has been studied by combining molecular biology, physiology and electron microscopy at the squid giant synapse. Procedures that prevent clathrin from assembling into membrane coats, such as impairment of binding of the AP180 and AP-2 adaptor proteins, completely prevent membrane budding during endocytosis. These procedures also reduce exocytosis, presumably an indirect effect of a reduction in the number of SVs following block of endocytosis. Disrupting the binding of auxilin to Hsc70 (heat-shock cognate 70) prevents clathrin-coated vesicles from uncoating and also disrupts SV recycling. Taken together, these results indicate that a clathrin-dependent pathway is the primary means of SV recycling at this synapse under physiological conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.