ReviewJournal of molecular medicine (Berlin, Germany)2006
Quantitative assessment of DNA methylation: Potential applications for disease diagnosis, classification, and prognosis in clinical settings.
Review in Journal of molecular medicine (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- The common bisulfite-conversion-based techniques to analyze DNA methylation in human cancers.Cancer cell international · 2024Review
- Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA.ACS applied materials & interfaces · 2022Article
- Base-Pairing Energies of Protonated Nucleoside Base Pairs of dCyd and m(5)dCyd: Implications for the Stability of DNA i-Motif Conformations.Journal of the American Society for Mass Spectrometry · 2015Article
- The epigenetics of prostate cancer diagnosis and prognosis: update on clinical applications.Current opinion in urology · 2015Review
- Silver(I) ions modulate the stability of DNA duplexes containing cytosine, methylcytosine and hydroxymethylcytosine at different salt concentrations.RSC advances · 2015Article
- Biomedical diagnosis perspective of epigenetic detections using alpha-hemolysin nanopore.AIMS materials science · 2015Article
- Single molecule investigation of Ag+ interactions with single cytosine-, methylcytosine- and hydroxymethylcytosine-cytosine mismatches in a nanopore.Scientific reports · 2014Article
- Hypermethylation of CpG islands is more prevalent than hypomethylation across the entire genome in breast carcinogenesis.Clinical and experimental medicine · 2013Article
- Toward the detection of prostate cancer in urine: a critical analysis.The Journal of urology · 2013Review
- A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies.Haematologica · 2012Article
- Hypermethylation of the gene LARP2 for noninvasive prenatal diagnosis of β-thalassemia based on DNA methylation profile.Molecular biology reports · 2012Article
- Genome-wide epigenetic modifications in cancer.Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques · 2011Review
- Epigenetic silencing of erythropoietin in human cancers.Genes & cancer · 2011Article
- Identification of epigenetic DNA modifications with a protein nanopore.Chemical communications (Cambridge, England) · 2010Article
- [DNA methylation. From basic research to routine diagnostics].Der Pathologe · 2010Article
- Chromatin remodeling in mammary gland differentiation and breast tumorigenesis.Cold Spring Harbor perspectives in biology · 2010Review
- Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action.Steroids · 2010Review
- Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer.Oncogene · 2010Article
- Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.Journal of translational medicine · 2009Article
- Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry.Analytical biochemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Deregulation of the epigenome is now recognized as a major mechanism involved in the development and progression of human diseases such as cancer. As opposed to the irreversible nature of genetic events, which introduce changes in the primary DNA sequence, epigenetic modifications are reversible and leave the original DNA sequence intact. There is now evidence that the epigenetic landscape in humans undergoes modifications as the result of normal aging, with older individuals exhibiting higher levels of promoter hypermethylation compared to younger ones. Thus, it has been proposed that the higher incidence of certain disease in older individuals might be, in part, a consequence of an inherent change in the control and regulation of the epigenome. These observations are of remarkable clinical significance since the aberrant epigenetic changes characteristic of disease provide a unique platform for the development of new therapeutic approaches. In this review, we address the significance of DNA methylation changes that result or lead to disease, occur with aging, or may be the result of environmental exposure. We provide a detailed description of quantitative techniques currently available for the detection and analysis of DNA methylation and provide a comprehensive framework that may allow for the incorporation of protocols which include DNA methylation as a tool for disease diagnosis and classification, which could lead to the tailoring of therapeutic approaches designed to individual patient needs.
Indexed as
Identifiers
16416310What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.